Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study

• Published in: Frontiers in cardiovascular medicine 2023-01, Vol.9, p.1081106
• Main Authors: Souilla, Luc, Avesani, Martina, Boisson, Aymeric, Requirand, Anne, Matecki, Stefan, Vincenti, Marie, Werner, Oscar, De La Villeon, Gregoire, Pommier, Victor, Pasquie, Jean-Luc, Guillaumont, Sophie, Amedro, Pascal
• Format: Article
• Language: English
• Subjects: cardiorespiratory fitness; Cardiovascular Medicine; inherited cardiac arrythmia; Life Sciences; long QT syndrome; muscle fitness; pediatrics; physical activity
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2022.1081106

In children with congenital long QT syndrome (LQTS), the risk of arrhythmic events during exercise commonly makes it difficult to balance exercise restrictions promotion of physical activity. Nevertheless, in children with LQTS, cardiorespiratory fitness, muscle fitness, and physical activity, have been scarcely explored. In this prospective, controlled, cross-sectional study, 20 children with LQTS (12.7 ± 3.7 years old) and 20 healthy controls (11.9 ± 2.4 years old) were enrolled. All participants underwent a cardiopulmonary exercise test, a muscular architecture ultrasound assessment, (cross-sectional area on right rectus femoris and pennation angle), a handgrip muscular strength evaluation, and a standing long broad jump test. The level of physical activity was determined using with a waist-worn tri-axial accelerometer (Actigraph GT3X). Peak oxygen uptake (VO ) and ventilatory anaerobic threshold (VAT) were lower in children with LQTS than in healthy controls (33.9 ± 6.2 mL/Kg/min 40.1 ± 6.6 mL/Kg/min, = 0.010; 23.8 ± 5.1 mL/Kg/min 28.8 ± 5.5 mL/Kg/min, = 0.007, respectively). Children with LQTS had lower standing long broad jump distance (119.5 ± 33.2 cm 147.3 ± 36.1 cm, = 0.02) and pennation angle (12.2 ± 2.4° 14.3 ± 2.8°, = 0.02). No differences in terms of moderate-to-vigorous physical activity were observed (36.9 ± 12.9 min/day 41.5 ± 18.7 min/day, = 0.66), but nearly all children were below the WHO guidelines. Despite similar physical activity level, cardiorespiratory fitness and muscle fitness in children with LQTS were lower than in healthy controls. The origin of this limitation seemed to be multifactorial, involving beta-blocker induced chronotropic limitation, physical and muscle deconditioning. Cardiovascular rehabilitation could be of interest in children with LQTS with significant physical limitation.