Peripapillary Microvascular Parameters in Unilateral Open-Angle Glaucoma Using the Optical Coherence Tomography-Angiography

Objective: This study compared the peripapillary retinal nerve fiber layer (pRNFL) microangiographic properties [vessel area density (VAD) and blood flux index (BFI)] of unilateral open-angle glaucomatous eyes to contralateral eyes-at-risk, and to eyes of healthy age- and sex-matched subjects. Metho...

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Bibliographic Details
Published in:Philippine journal of ophthalmology 2022-12, Vol.47 (2), p.56-63
Main Authors: Victor Ephraime V. Paulino, MD, DPBO, John Mark S. de Leon, MD, DPBO
Format: Article
Language:English
Subjects:
blood flux index
oct-angiography
peripapillary microcirculation
unilateral glaucoma
vessel area density
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Summary:Objective: This study compared the peripapillary retinal nerve fiber layer (pRNFL) microangiographic properties [vessel area density (VAD) and blood flux index (BFI)] of unilateral open-angle glaucomatous eyes to contralateral eyes-at-risk, and to eyes of healthy age- and sex-matched subjects. Methods: This was a single-center, case-control study of Filipinos diagnosed with unilateral primary openangle glaucoma (POAG) or normal-tension glaucoma (NTG). Mean overall and quadrantal VAD and BFI of the three groups were measured with optical coherence tomography- angiography (OCT-A). Area under the receiver operating characteristic (AROC) was used to measure diagnostic ability. Results: Twenty-two (22) glaucomatous subjects (15 POAG and 7 NTG eyes), 22 contralateral eyes-at-risk, and 22 normal eyes from age- and sex-matched control subjects completed the study. Eyes with glaucoma showed lower mean overall VAD (40%) and BFI (0.37) compared to eyes-at-risk (44.4% and 0.42, respectively; p
ISSN:0031-7659