Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder

Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the h...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neural transplantation & plasticity 2015-01, Vol.2015 (2015), p.420-426-035
Main Authors: Tramontina, Silzá, Rohde, Luis Augusto, Zeni, Cristian Patrick, de Aguiar, Bianca Wollenhaupt, Peters, Roberta, Brun, Juliana Basso, Rodrigues, Ramiro Borges, Souza, Ana Claudia Mércio Loredo, Kohmann, Andre de Moura, Anes, Mauricio, Lauxen Peruzzolo, Tatiana, Kapczinski, Flavio
Format: Article
Language:English
Subjects:
Adolescent
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - pathology
Brain research
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Child
Children & youth
Cross-Sectional Studies
Data analysis
Female
Hippocampus (Brain)
Hippocampus - pathology
Humans
Magnetic resonance imaging
Male
Medical imaging
Memory
Mental disorders
Neurogenesis
Neuropsychological Tests
Pediatrics
Schizophrenia
Teenagers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children and Adolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm3, respectively. No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found. We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolescents. Besides studies with larger sample sizes to confirm the present findings and longitudinal assessments, addressing brain development versus a control group and including drug-naive patients in different mood states may help clarify the role of BDNF in the brain changes consequent upon BD.
ISSN:0792-8483
2090-5904
1687-5443
DOI:10.1155/2015/324825