Current coffee consumption is associated with decreased striatal dopamine transporter availability in Parkinson's disease patients and healthy controls

Coffee is the most widely consumed psychostimulant worldwide. Emerging evidence indicates that coffee consumption habit significantly reduces the risk of developing Parkinson's disease (PD). However, the effect of coffee consumption on nigrostriatal dopaminergic neurodegeneration is still large...

Full description

Saved in:
Bibliographic Details
Published in:BMC medicine 2023-07, Vol.21 (1), p.272-272, Article 272
Main Authors: Wang, Chao, Zhou, Cheng, Guo, Tao, Jiaerken, Yeerfan, Yang, Siyu, Xu, Xiaopei, Hu, Ling, Huang, Peiyu, Xu, Xiaojun, Zhang, Minming
Format: Article
Language:English
Subjects:
Analysis
Availability
Caffeine
Care and treatment
Caudate
Caudate nucleus
Coffee
Comparative analysis
Consumers
Consumption
Consumption data
Correlation analysis
Cups
Diagnosis
Disease control
Dopamine
Dopamine receptors
Dopamine transporter
Gender
Health aspects
Marketing research
Medical research
Medicine, Experimental
Movement disorders
Neostriatum
Neurodegeneration
Neurodegenerative diseases
Normal distribution
Parkinson's disease
Phenols
Questionnaires
Regression analysis
Striatum
Subgroups
Variance analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Coffee is the most widely consumed psychostimulant worldwide. Emerging evidence indicates that coffee consumption habit significantly reduces the risk of developing Parkinson's disease (PD). However, the effect of coffee consumption on nigrostriatal dopaminergic neurodegeneration is still largely unknown. We therefore aim to investigate the role of coffee consumption in nigrostriatal dopaminergic neurodegeneration using dopamine transporter (DAT) imaging in PD and healthy controls (HC). A total of 138 PD patients and 75 HC with questionnaires about coffee consumption, and DAT scans were recruited from the Parkinson's Progression Markers Initiative cohort. Demographic, clinical, and striatal DAT characteristics were compared across subgroups of current, former, and never coffee consumers in PD and HC, respectively. Furthermore, partial correlation analyses were performed to determine whether there was a relationship between coffee cups consumed per day and striatal DAT characteristics in each striatal region. In addition, the factors that may have influenced the loss of nigrostriatal dopaminergic neurons were included in multiple linear regression analyses to identify significant contributing factors to DAT availability in each striatal region. PD patients had lower DAT availability in each striatal region than HC (p 
ISSN:1741-7015
1741-7015
DOI:10.1186/s12916-023-02994-5