Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γ and Plasminogen Activator Inhibitor-1

Breast cancer is the most prominent cancer among females in the United States. There are a number of risk factors associated with development of breast cancer, including consumption of a high-fat diet and obesity. Plasminogen activator inhibitor-1 (PAI-1) is a cytokine upregulated in obesity whose e...

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Bibliographic Details
Published in:PPAR Research 2009-01, Vol.2009 (2009), p.42-54
Main Authors: Carter, Jennifer C., Church, Frank C.
Format: Article
Language:English
Subjects:
Breast cancer
Cell receptors
Complications and side effects
Development and progression
Health aspects
Ketogenic diet
Obesity
Properties
Review
Risk factors
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Summary:Breast cancer is the most prominent cancer among females in the United States. There are a number of risk factors associated with development of breast cancer, including consumption of a high-fat diet and obesity. Plasminogen activator inhibitor-1 (PAI-1) is a cytokine upregulated in obesity whose expression is correlated with a poor prognosis in breast cancer. As a key mediator of adipogenesis and regulator of adipokine production, peroxisome proliferator-activated receptor-γ (PPAR-γ) is involved in PAI-1 expression from adipose tissue. We summarize the current knowledge linking PPAR-γ and PAI-1 expression to high-fat diet and obesity in the risk of breast cancer.
ISSN:1687-4757
1687-4765
DOI:10.1155/2009/345320