The Swine Erysipelas Vaccine SER-ME Effectively Protects Pigs against Challenge with the Erysipelothrix rhusiopathiae M203/I257 SpaA-Type Variant

Erysipelothrix rhusiopathiae causes swine erysipelas (SE). Sporadic SE outbreaks in Japan are mostly caused by the E. rhusiopathiae serovar 1a variant featured by methionine (M) and isoleucine (I) at amino acid positions 203 and 257 of the surface protective antigen (Spa) A protein (M203/I257 SpaA-t...

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Published in:Veterinary sciences 2022-07, Vol.9 (8), p.382
Main Authors: Morimoto, Misako, Kato, Atsushi, Nogami, Kotoe, Akaike, Yuta, Furusawa, Takaaki, Kojima, Hiroe, Sasakawa, Chihiro
Format: Article
Language:English
Subjects:
Amino acids
Antibodies
Antigens
Arthritis
Communication
Epidemics
Erysipelas
Erysipelothrix rhusiopathiae
Hogs
Isoleucine
Methionine
Outbreaks
Protective antigen
Proteins
SpaA
Swine erysipelas
Urticaria
vaccine efficacy
Vaccines
variant
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container_issue 8
container_start_page 382
container_title Veterinary sciences
container_volume 9
creator Morimoto, Misako
Kato, Atsushi
Nogami, Kotoe
Akaike, Yuta
Furusawa, Takaaki
Kojima, Hiroe
Sasakawa, Chihiro
description Erysipelothrix rhusiopathiae causes swine erysipelas (SE). Sporadic SE outbreaks in Japan are mostly caused by the E. rhusiopathiae serovar 1a variant featured by methionine (M) and isoleucine (I) at amino acid positions 203 and 257 of the surface protective antigen (Spa) A protein (M203/I257 SpaA-type). To determine if current vaccines are effective against infection with this variant in pigs, one representative inactivated vaccine, SER-ME (containing E. rhusiopathiae serovar 2a), was evaluated. All vaccinated pigs survived without any apparent clinical signs after lethal challenge with the Fujisawa reference strain or the variant. This indicates that the SER-ME vaccine effectively protects pigs against the infection of E. rhusiopathiae M203/I257 SpaA-type variant. Current vaccines in Japan, including SER-ME, suggest that outbreaks in Japan are unlikely caused by vaccine failure.
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ispartof Veterinary sciences, 2022-07, Vol.9 (8), p.382
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subjects Amino acids
Antibodies
Antigens
Arthritis
Communication
Epidemics
Erysipelas
Erysipelothrix rhusiopathiae
Hogs
Isoleucine
Methionine
Outbreaks
Protective antigen
Proteins
SpaA
Swine erysipelas
Urticaria
vaccine efficacy
Vaccines
variant
title The Swine Erysipelas Vaccine SER-ME Effectively Protects Pigs against Challenge with the Erysipelothrix rhusiopathiae M203/I257 SpaA-Type Variant
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