Ameliorating effects of Acacia arabica and Ocimum basilicum on acetic acid-induced ulcerative colitis model through mitigation of inflammation and oxidative stress

• Published in: Heliyon 2023-11, Vol.9 (11), p.e22355-e22355, Article e22355
• Main Authors: Bejeshk, Mohammad Abbas, Aminizadeh, Amir Hashem, Rajizadeh, Mohammad Amin, Rostamabadi, Fahimeh, Bagheri, Fatemeh, Khaksari, Mohammad, Azimi, Maryam
• Format: Article
• Language: English
• Subjects: Acacia arabica; Acetic acid-induced ulcerative colitis inflammation; Basil seed; Gum Arabic; Ocimum basilicum; Stress oxidative
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2023.e22355

Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the large intestine and rectum. The disease is characterized by oxidative stress and severe inflammation. Research has shown the anti-oxidative and anti-inflammatory effects induced by consuming the Acacia arabia and Ocimum basilicum. The present study aimed to evaluate the effect of treatment with O. basilicum together with A. arabica on healing, inflammation, and oxidative stress in the course of experimental colitis in rats. A total number of 50 male rats were selected and randomly assigned to five groups of 10 rats each. Colitis was induced in rats by enemas with a 4 % acetic acid solution. Four days after the colitis induction, the rats were orally treated for the next 4 days with saline or a combination of A. arabica and O. basilicum (1000 mg/kg) or sulfasalazine (100 mg/kg). Acetic acid-induced colitis increased the colon's macroscopic and histopathological damage scores; increased colon levels of MDA (Malondialdehyde), MPO (Myeloperoxidase), TNF-α (Tissue necrosis factor α), IL6 (Interleukin 6), and IL17 (Interleukin 17); and decreased SOD (Superoxide Dismutase), GPx (Glutathione Peroxidase), and IL10 (Interleukin 10) levels in the treated rats compared with the control group (P