Anti-oxidative and anti-proliferative activity on human prostate cancer cells lines of the phenolic compounds from Corylopsis coreana Uyeki

Fifteen phenolic compounds, including three caffeoyl derivatives, four gallotannins, three ellagitannins and five flavonoids, were isolated from an 80% MeOH extract of the leaves of Corylopsis coreana Uyeki (Korean winter hazel; CL). The anti-oxidative activities [1,1-diphenyl-2-picrylhydrazyl (DPPH...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2013-04, Vol.18 (5), p.4876-4886
Main Authors: Kim, Manh Heun, Ha, Sung Yi, Oh, Myeong Hwan, Kim, Han Hyuk, Kim, So Ra, Lee, Min Won
Format: Article
Language:English
Subjects:
1,1-diphenyl-2-picrylhydazyl radical
Acids
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants - chemistry
Antioxidants - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
Corylopsis coreana. Uyeki
Drug Screening Assays, Antitumor
DU145
Hamamelidaceae - chemistry
Humans
LNCaP
Male
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
superoxide scavenging
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Summary:Fifteen phenolic compounds, including three caffeoyl derivatives, four gallotannins, three ellagitannins and five flavonoids, were isolated from an 80% MeOH extract of the leaves of Corylopsis coreana Uyeki (Korean winter hazel; CL). The anti-oxidative activities [1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and xanthine oxidase superoxide scavenging activities (NBT)] and the anti-proliferative activity on human prostate cancer cell lines (DU145 and LNCaP) were also evaluated.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules18054876