Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype

Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription...

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Bibliographic Details
Published in:Stem cell research 2018-05, Vol.29, p.250-253
Main Authors: Peitz, Michael, Bechler, Tamara, Thiele, Catrin Cornelia, Veltel, Monika, Bloschies, Melanie, Fliessbach, Klaus, Ramirez, Alfredo, Brüstle, Oliver
Format: Article
Language:English
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Summary:Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2018.04.011