Circulating ESM-1 levels are correlated with the presence of coronary artery disease in patients with obstructive sleep apnea

• Published in: Respiratory research 2019-08, Vol.20 (1), p.188-188, Article 188
• Main Authors: Sun, Haili, Fang, Fang, Li, Kun, Zhang, Huina, Zhang, Ming, Zhang, Lichuan, Li, Juan, Qin, Yanwen, Wei, Yongxiang
• Format: Article
• Language: English
• Subjects: Adult; Aged; Apnea; Arteriosclerosis; Atherosclerosis; Bioindicators; Biomarker; Biomarkers; Biomarkers - blood; Cardiovascular disease; Cardiovascular diseases; Complications and side effects; Coronary Angiography; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - etiology; Coronary heart disease; Coronary vessels; Cross-Sectional Studies; Development and progression; Endothelial cell specific molecules-1(ESM-1); Endothelial cells; Endothelial dysfunction; Female; Heart diseases; Humans; Male; Middle Aged; Multivariate analysis; Neoplasm Proteins - blood; Obstructive sleep apnea; Polysomnography; Predictive Value of Tests; Proteoglycans - blood; Regression analysis; Reproducibility of Results; Risk analysis; Risk Factors; Sleep; Sleep apnea; Sleep Apnea, Obstructive - complications; Sleep disorders; Stenosis
• ISSN: 1465-993X; 1465-9921; 1465-993X; 1465-9921
• DOI: 10.1186/s12931-019-1143-6

Endothelial dysfunction is one of the most important early indicators of atherosclerosis in obstructive sleep apnea (OSA) patients. Endothelial cell specific molecules-1 (ESM-1), which is a novel endothelial dysfunction marker that may be linked to cardiovascular disease. We investigated to assess whether circulating ESM-1 levels are correlated with the presence of coronary artery disease (CAD) in patients with OSA. We performed a cross-sectional study in 228 Chinese OSA subjects, including 185 patients with OSA and 43 controls. The Gensini stenosis scoring system was used to assess the severity of CAD. Circulating ESM-1 levels were measured by Human Magnetic Luminex Screening Assay. The associations between circulating ESM-1 levels and CAD were determined by multivariate logistic regression analysis. The association between ESM-1 levels and Gensini scores was determined by multivariate linear regression analysis. CAD patients had significantly higher circulating ESM-1 levels compared with non-CAD patients (1279.01[918.52-1770.71] pg/ml vs 585.46[423.61-812.56] pg/ml, P