Association of Lower Extremity Muscle Strength and Function with Renal Resistive Index in Individuals with and without Chronic Kidney Disease

Age-related loss of lower extremity muscle strength is pronounced in individuals with chronic kidney disease (CKD). In contrast, an increase in intrarenal flow pulsatility results in initial age-related changes in renal hemodynamics, leading to the development of CKD. To date, it remains unclear whe...

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Published in:Geriatrics (Basel) 2023-12, Vol.8 (6), p.118
Main Authors: Nishitani, Natsumi, Kosaki, Keisei, Mori, Shoya, Matsui, Masahiro, Sugaya, Takeshi, Kuro-O, Makoto, Saito, Chie, Yamagata, Kunihiro, Maeda, Seiji
Format: Article
Language:English
Subjects:
Blood pressure
Cardiovascular disease
chronic kidney disease
Creatinine
Diabetes
Exercise
Flow velocity
Hemodynamics
Hypertension
Investigations
Kidney diseases
lower extremity
Medical technology
Metabolism
Muscle strength
Older people
renal flow pulsatility
renal resistive index
Ultrasonic imaging
Veins & arteries
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Summary:Age-related loss of lower extremity muscle strength is pronounced in individuals with chronic kidney disease (CKD). In contrast, an increase in intrarenal flow pulsatility results in initial age-related changes in renal hemodynamics, leading to the development of CKD. To date, it remains unclear whether lower extremity muscle strength determines elevated renal flow pulsatility. This study aimed to determine the association of lower extremity muscle strength and function with intrarenal hemodynamics in individuals with and without CKD. One hundred seventy-six individuals without CKD (aged 63 ± 9 years) and 101 individuals with CKD (aged 66 ± 8 years) were included in this study. Using Doppler ultrasound, the renal resistive index (RI) was measured as a parameter of renal hemodynamics. Knee extensor muscle strength (KES), gait speed (GS), and the 30 s chair stand test (30s-CST) were used to measure lower extremity muscle strength and function. Multivariate analyses showed that GS and 30s-CST scores were independent determinants of renal RI, whereas the KES score was not associated with renal RI in individuals with and without CKD. In the two-way analysis of covariance, renal RI was the highest in individuals with CKD who had lower KES, GS, and 30s-CST scores. Reduced lower extremity muscle strength and function are independent determinants of elevated renal flow pulsatility in individuals with and without CKD.
ISSN:2308-3417
2308-3417
DOI:10.3390/geriatrics8060118