Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity

Obesity-induced adipose tissue dysfunction is bolstered by chronic, low-grade inflammation and impairs systemic metabolic health. Adipose tissue macrophages (ATMs) perpetuate local inflammation but are crucial to adipose tissue homeostasis, exerting heterogeneous, niche-specific functions. Diversifi...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-04, Vol.11 (8), p.1336
Main Authors: Matz, Alyssa, Qu, Lili, Karlinsey, Keaton, Zhou, Beiyan
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - metabolism
Biosynthesis
Body fat
Cell activation
Homeostasis
Humans
Immune response
Inflammation
Inflammation - metabolism
Insulin resistance
macrophage
Macrophages
Macrophages - metabolism
microRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Obesity
Obesity - metabolism
Post-transcription
Proteins
Review
RNA polymerase
Transcription activation
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Summary:Obesity-induced adipose tissue dysfunction is bolstered by chronic, low-grade inflammation and impairs systemic metabolic health. Adipose tissue macrophages (ATMs) perpetuate local inflammation but are crucial to adipose tissue homeostasis, exerting heterogeneous, niche-specific functions. Diversified macrophage actions are shaped through finely regulated factors, including microRNAs, which post-transcriptionally alter macrophage activation. Numerous studies have highlighted microRNAs' importance to immune function and potential as inflammation-modulatory. This review summarizes current knowledge of regulatory networks governed by microRNAs in ATMs in white adipose tissue under obesity stress.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11081336