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Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections
Toxoplasmosis and neosporosis are major protozoan diseases of global distribution. is the cause of toxoplasmosis, which affects almost all warm-blooded animals, including humans, while induces neosporosis in many animal species, especially cattle. The current defective situation with control measure...
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| Published in: | Vaccines (Basel) 2022-12, Vol.10 (12), p.2082 |
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| creator | Fereig, Ragab M Omar, Mosaab A Alsayeqh, Abdullah F |
| description | Toxoplasmosis and neosporosis are major protozoan diseases of global distribution.
is the cause of toxoplasmosis, which affects almost all warm-blooded animals, including humans, while
induces neosporosis in many animal species, especially cattle. The current defective situation with control measures is hindering all efforts to overcome the health hazards and economic losses of toxoplasmosis and neosporosis. Adequate understanding of host-parasite interactions and host strategies to combat such infections can be exploited in establishing potent control measures, including vaccine development. Macrophages are the first defense line of innate immunity, which is responsible for the successful elimination of
or
. This action is exerted via the immunoregulatory interleukin-12 (IL-12), which orchestrates the production of interferon gamma (IFN-γ) from various immune cells. Cellular immune response and IFN-γ production is the hallmark for successful vaccine candidates against both
and
. However, the discovery of potential vaccine candidates is a highly laborious, time-consuming and expensive procedure. In this review, we will try to exploit previous knowledge and our research experience to establish an efficient immunological approach for exploring potential vaccine candidates against
and
. Our previous studies on vaccine development against both
and
revealed a strong association between the successful and potential vaccine antigens and their ability to promote the macrophage secretion of IL-12 using a murine model. This phenomenon was emphasized using different recombinant antigens, parasites, and experimental approaches. Upon these data and research trials, IL-12 production from murine macrophages can be used as an initial predictor for judgment of vaccine efficacy before further evaluation in time-consuming and laborious in vivo experiments. However, more studies and research are required to conceptualize this immunological approach. |
| doi_str_mv | 10.3390/vaccines10122082 |
| format | article |
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is the cause of toxoplasmosis, which affects almost all warm-blooded animals, including humans, while
induces neosporosis in many animal species, especially cattle. The current defective situation with control measures is hindering all efforts to overcome the health hazards and economic losses of toxoplasmosis and neosporosis. Adequate understanding of host-parasite interactions and host strategies to combat such infections can be exploited in establishing potent control measures, including vaccine development. Macrophages are the first defense line of innate immunity, which is responsible for the successful elimination of
or
. This action is exerted via the immunoregulatory interleukin-12 (IL-12), which orchestrates the production of interferon gamma (IFN-γ) from various immune cells. Cellular immune response and IFN-γ production is the hallmark for successful vaccine candidates against both
and
. However, the discovery of potential vaccine candidates is a highly laborious, time-consuming and expensive procedure. In this review, we will try to exploit previous knowledge and our research experience to establish an efficient immunological approach for exploring potential vaccine candidates against
and
. Our previous studies on vaccine development against both
and
revealed a strong association between the successful and potential vaccine antigens and their ability to promote the macrophage secretion of IL-12 using a murine model. This phenomenon was emphasized using different recombinant antigens, parasites, and experimental approaches. Upon these data and research trials, IL-12 production from murine macrophages can be used as an initial predictor for judgment of vaccine efficacy before further evaluation in time-consuming and laborious in vivo experiments. However, more studies and research are required to conceptualize this immunological approach.</description><identifier>ISSN: 2076-393X</identifier><identifier>EISSN: 2076-393X</identifier><identifier>DOI: 10.3390/vaccines10122082</identifier><identifier>PMID: 36560492</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abortion ; Animal models ; Animal species ; Animals ; antigen ; Antigens ; Calcification ; Cattle ; Congenital diseases ; Cysts ; Economic impact ; Epidemiology ; Health hazards ; Homeotherms ; Host-parasite interactions ; Immune response ; Immune response (cell-mediated) ; Immune system ; Immunology ; Immunoregulation ; In vivo methods and tests ; Infections ; Innate immunity ; Interleukin 12 ; Macrophages ; Medical research ; N. caninum ; Neospora caninum ; Neosporosis ; Parasites ; Pathogenesis ; Physiology ; Proteins ; Protozoa ; R&D ; Research & development ; Review ; Sheep ; T. gondii ; Toxoplasma gondii ; Toxoplasmosis ; vaccine ; Vaccine development ; Vaccine efficacy ; Vaccines ; Virulence ; γ-Interferon</subject><ispartof>Vaccines (Basel), 2022-12, Vol.10 (12), p.2082</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-f03028b35b9256a40fbcc69ba51fd195d1d227484f67e5e48e3ce7998cb84b03</citedby><cites>FETCH-LOGICAL-c490t-f03028b35b9256a40fbcc69ba51fd195d1d227484f67e5e48e3ce7998cb84b03</cites><orcidid>0000-0003-1845-1312 ; 0000-0001-9869-2874 ; 0000-0003-1553-1763</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2756819551/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2756819551?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36560492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fereig, Ragab M</creatorcontrib><creatorcontrib>Omar, Mosaab A</creatorcontrib><creatorcontrib>Alsayeqh, Abdullah F</creatorcontrib><title>Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections</title><title>Vaccines (Basel)</title><addtitle>Vaccines (Basel)</addtitle><description>Toxoplasmosis and neosporosis are major protozoan diseases of global distribution.
is the cause of toxoplasmosis, which affects almost all warm-blooded animals, including humans, while
induces neosporosis in many animal species, especially cattle. The current defective situation with control measures is hindering all efforts to overcome the health hazards and economic losses of toxoplasmosis and neosporosis. Adequate understanding of host-parasite interactions and host strategies to combat such infections can be exploited in establishing potent control measures, including vaccine development. Macrophages are the first defense line of innate immunity, which is responsible for the successful elimination of
or
. This action is exerted via the immunoregulatory interleukin-12 (IL-12), which orchestrates the production of interferon gamma (IFN-γ) from various immune cells. Cellular immune response and IFN-γ production is the hallmark for successful vaccine candidates against both
and
. However, the discovery of potential vaccine candidates is a highly laborious, time-consuming and expensive procedure. In this review, we will try to exploit previous knowledge and our research experience to establish an efficient immunological approach for exploring potential vaccine candidates against
and
. Our previous studies on vaccine development against both
and
revealed a strong association between the successful and potential vaccine antigens and their ability to promote the macrophage secretion of IL-12 using a murine model. This phenomenon was emphasized using different recombinant antigens, parasites, and experimental approaches. Upon these data and research trials, IL-12 production from murine macrophages can be used as an initial predictor for judgment of vaccine efficacy before further evaluation in time-consuming and laborious in vivo experiments. However, more studies and research are required to conceptualize this immunological approach.</description><subject>Abortion</subject><subject>Animal models</subject><subject>Animal species</subject><subject>Animals</subject><subject>antigen</subject><subject>Antigens</subject><subject>Calcification</subject><subject>Cattle</subject><subject>Congenital diseases</subject><subject>Cysts</subject><subject>Economic impact</subject><subject>Epidemiology</subject><subject>Health hazards</subject><subject>Homeotherms</subject><subject>Host-parasite interactions</subject><subject>Immune response</subject><subject>Immune response (cell-mediated)</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Immunoregulation</subject><subject>In vivo methods and tests</subject><subject>Infections</subject><subject>Innate immunity</subject><subject>Interleukin 12</subject><subject>Macrophages</subject><subject>Medical research</subject><subject>N. caninum</subject><subject>Neospora caninum</subject><subject>Neosporosis</subject><subject>Parasites</subject><subject>Pathogenesis</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Protozoa</subject><subject>R&D</subject><subject>Research & development</subject><subject>Review</subject><subject>Sheep</subject><subject>T. gondii</subject><subject>Toxoplasma gondii</subject><subject>Toxoplasmosis</subject><subject>vaccine</subject><subject>Vaccine development</subject><subject>Vaccine efficacy</subject><subject>Vaccines</subject><subject>Virulence</subject><subject>γ-Interferon</subject><issn>2076-393X</issn><issn>2076-393X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdUk1v1DAUjBCIVqV3TsgSFy6BZzsf9gUJlQIrLR-HFeJmOc5z1qvEDnayKj-C_0x2t1RtfbH1PG_ejD1Z9pLCW84lvNtrY5zHRIEyBoI9yc4Z1FXOJf_19N75LLtMaQfLkpSLqn6enfGqrKCQ7Dz7e30z9sFNzndk2iL5qk0M41Z3SH7E0M5mcsGTYMlqnVNGnCerYYxhjwP66VD_eVJBPuIe-zAey7rTzqeJbMJNGHudBk264FvniPYt-YYhjSFqYrR3fh7Iyls8zkkvsmdW9wkvb_eLbPPpenP1JV9__7y6-rDOTSFhyi1wYKLhZSNZWekCbGNMJRtdUttSWba0ZawuRGGrGkssBHKDtZTCNKJogF9kqxNtG_ROjdENOv5RQTt1LITYKR0nZ3pUDJhpSiipsLqoJDRoLSzzOEANKOjC9f7ENc7NgK1Z_EfdPyB9eOPdVnVhr2QtOK-KheDNLUEMv2dMkxpcMtj32mOYk2J1KSjUnIkF-voRdBfm6JeXOqAqsVgvD4rghFp-MqWI9k4MBXVIjnqcnKXl1X0Tdw3_c8L_Ad8owrQ</recordid><startdate>20221206</startdate><enddate>20221206</enddate><creator>Fereig, Ragab M</creator><creator>Omar, Mosaab A</creator><creator>Alsayeqh, Abdullah F</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1845-1312</orcidid><orcidid>https://orcid.org/0000-0001-9869-2874</orcidid><orcidid>https://orcid.org/0000-0003-1553-1763</orcidid></search><sort><creationdate>20221206</creationdate><title>Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections</title><author>Fereig, Ragab M ; Omar, Mosaab A ; Alsayeqh, Abdullah F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-f03028b35b9256a40fbcc69ba51fd195d1d227484f67e5e48e3ce7998cb84b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abortion</topic><topic>Animal models</topic><topic>Animal species</topic><topic>Animals</topic><topic>antigen</topic><topic>Antigens</topic><topic>Calcification</topic><topic>Cattle</topic><topic>Congenital diseases</topic><topic>Cysts</topic><topic>Economic impact</topic><topic>Epidemiology</topic><topic>Health hazards</topic><topic>Homeotherms</topic><topic>Host-parasite interactions</topic><topic>Immune response</topic><topic>Immune response (cell-mediated)</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Immunoregulation</topic><topic>In vivo methods and tests</topic><topic>Infections</topic><topic>Innate immunity</topic><topic>Interleukin 12</topic><topic>Macrophages</topic><topic>Medical research</topic><topic>N. caninum</topic><topic>Neospora caninum</topic><topic>Neosporosis</topic><topic>Parasites</topic><topic>Pathogenesis</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Protozoa</topic><topic>R&D</topic><topic>Research & development</topic><topic>Review</topic><topic>Sheep</topic><topic>T. gondii</topic><topic>Toxoplasma gondii</topic><topic>Toxoplasmosis</topic><topic>vaccine</topic><topic>Vaccine development</topic><topic>Vaccine efficacy</topic><topic>Vaccines</topic><topic>Virulence</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fereig, Ragab M</creatorcontrib><creatorcontrib>Omar, Mosaab A</creatorcontrib><creatorcontrib>Alsayeqh, Abdullah F</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library (ProQuest)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Vaccines (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fereig, Ragab M</au><au>Omar, Mosaab A</au><au>Alsayeqh, Abdullah F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections</atitle><jtitle>Vaccines (Basel)</jtitle><addtitle>Vaccines (Basel)</addtitle><date>2022-12-06</date><risdate>2022</risdate><volume>10</volume><issue>12</issue><spage>2082</spage><pages>2082-</pages><issn>2076-393X</issn><eissn>2076-393X</eissn><abstract>Toxoplasmosis and neosporosis are major protozoan diseases of global distribution.
is the cause of toxoplasmosis, which affects almost all warm-blooded animals, including humans, while
induces neosporosis in many animal species, especially cattle. The current defective situation with control measures is hindering all efforts to overcome the health hazards and economic losses of toxoplasmosis and neosporosis. Adequate understanding of host-parasite interactions and host strategies to combat such infections can be exploited in establishing potent control measures, including vaccine development. Macrophages are the first defense line of innate immunity, which is responsible for the successful elimination of
or
. This action is exerted via the immunoregulatory interleukin-12 (IL-12), which orchestrates the production of interferon gamma (IFN-γ) from various immune cells. Cellular immune response and IFN-γ production is the hallmark for successful vaccine candidates against both
and
. However, the discovery of potential vaccine candidates is a highly laborious, time-consuming and expensive procedure. In this review, we will try to exploit previous knowledge and our research experience to establish an efficient immunological approach for exploring potential vaccine candidates against
and
. Our previous studies on vaccine development against both
and
revealed a strong association between the successful and potential vaccine antigens and their ability to promote the macrophage secretion of IL-12 using a murine model. This phenomenon was emphasized using different recombinant antigens, parasites, and experimental approaches. Upon these data and research trials, IL-12 production from murine macrophages can be used as an initial predictor for judgment of vaccine efficacy before further evaluation in time-consuming and laborious in vivo experiments. However, more studies and research are required to conceptualize this immunological approach.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36560492</pmid><doi>10.3390/vaccines10122082</doi><orcidid>https://orcid.org/0000-0003-1845-1312</orcidid><orcidid>https://orcid.org/0000-0001-9869-2874</orcidid><orcidid>https://orcid.org/0000-0003-1553-1763</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Vaccines (Basel), 2022-12, Vol.10 (12), p.2082 |
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| subjects | Abortion Animal models Animal species Animals antigen Antigens Calcification Cattle Congenital diseases Cysts Economic impact Epidemiology Health hazards Homeotherms Host-parasite interactions Immune response Immune response (cell-mediated) Immune system Immunology Immunoregulation In vivo methods and tests Infections Innate immunity Interleukin 12 Macrophages Medical research N. caninum Neospora caninum Neosporosis Parasites Pathogenesis Physiology Proteins Protozoa R&D Research & development Review Sheep T. gondii Toxoplasma gondii Toxoplasmosis vaccine Vaccine development Vaccine efficacy Vaccines Virulence γ-Interferon |
| title | Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development against Toxoplasma gondii and Neospora caninum Infections |
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