Estimated GFR, Albuminuria, and Physical Function: The Brain in Kidney Disease (BRINK) Cohort StudyPlain-Language Summary

Rationale & Objective: Chronic kidney disease (CKD) is associated with impaired physical performance. However, the association between albuminuria, a marker of vascular endothelial dysfunction, and physical performance has not been fully characterized. We hypothesized that estimated glomerular f...

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Bibliographic Details
Published in:Kidney medicine 2022-10, Vol.4 (10), p.100531
Main Authors: Ryan Mello, Kirsten L. Johansen, Anne Murray, Cynthia Davey, Allyson Hart
Format: Article
Language:English
Subjects:
Albuminuria
CKD
eGFR
frailty
physical performance
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Summary:Rationale & Objective: Chronic kidney disease (CKD) is associated with impaired physical performance. However, the association between albuminuria, a marker of vascular endothelial dysfunction, and physical performance has not been fully characterized. We hypothesized that estimated glomerular filtration rate (eGFR) and albuminuria would be independently associated with physical performance. Study Design: Cross-sectional analysis. Setting & Participants: A total of 571 adults with and without CKD. Predictors: Creatinine-based eGFR (eGFRCr) and cystatin C-based eGFR (eGFRCysC) and urine albumin to creatinine ratio (UACR). Outcome: Short Physical Performance Battery (SPPB). Analytical Approach: Univariate and multivariable logistic regression models were used to examine associations of eGFR and UACR with impaired physical performance. Results: Of the 571 participants (mean age, 69.3 years), 157 (27.5%) had eGFRCr (mL/min/1.73m2) 
ISSN:2590-0595
2590-0595