Superparamagnetic Iron Oxide Nanoparticles Decorated Mesoporous Silica Nanosystem for Combined Antibiofilm Therapy

A crucial challenge to face in the treatment of biofilm-associated infection is the ability of bacteria to develop resistance to traditional antimicrobial therapies based on the administration of antibiotics alone. This study aims to apply magnetic hyperthermia together with controlled antibiotic de...

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Bibliographic Details
Published in:Pharmaceutics 2022-01, Vol.14 (1), p.163
Main Authors: Álvarez, Elena, Estévez, Manuel, Gallo-Cordova, Alvaro, González, Blanca, Castillo, Rafael R, Morales, María Del Puerto, Colilla, Montserrat, Izquierdo-Barba, Isabel, Vallet-Regí, María
Format: Article
Language:English
Subjects:
Acids
antibiotic delivery
Antibiotics
Antimicrobial agents
Bacteria
bacterial biofilm
Bacterial infections
Biocompatibility
Biofilms
combined therapy
Ethanol
Fever
Hyperthermia
Infections
mesoporous silica nanoparticles
Nanoparticles
Phase transitions
superparamagnetic iron oxide nanoparticles
thermo-responsive polymer coating
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Summary:A crucial challenge to face in the treatment of biofilm-associated infection is the ability of bacteria to develop resistance to traditional antimicrobial therapies based on the administration of antibiotics alone. This study aims to apply magnetic hyperthermia together with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier for a combination therapy against biofilm. The design of the nanosystem is based on antibiotic-loaded mesoporous silica nanoparticles (MSNs) externally functionalized with a thermo-responsive polymer capping layer, and decorated in the outermost surface with superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs are able to generate heat upon application of an alternating magnetic field (AMF), reaching the temperature needed to induce a change in the polymer conformation from linear to globular, therefore triggering pore uncapping and the antibiotic cargo release. The microbiological assays indicated that exposure of biofilms to 200 µg/mL of the nanosystem and the application of an AMF (202 kHz, 30 mT) decreased the number of viable bacteria by 4 log units compared with the control. The results of the present study show that combined hyperthermia and antibiotic treatment is a promising approach for the effective management of biofilm-associated infections.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14010163