Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism

In recent years, ketogenic diets and ketone supplements have increased in popularity, particularly as a mechanism to improve exercise performance by modifying energetics. Since the skeletal muscle is a major metabolic and locomotory organ, it is important to take it into consideration when consideri...

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Bibliographic Details
Published in:Nutrients 2023-09, Vol.15 (19), p.4228
Main Authors: Khouri, Hannah, Ussher, John R, Aguer, Céline
Format: Article
Language:English
Subjects:
Carbohydrates
Diabetes
Diet
Enzymes
Exercise
exercise performance
Fitness equipment
Gene expression
Glucose
ketogenic diet
ketone bodies
ketone supplements
Metabolism
Muscles
Musculoskeletal system
Oxidation
Physical fitness
Physiological aspects
Protein expression
Proteins
Review
Running
skeletal muscle
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Summary:In recent years, ketogenic diets and ketone supplements have increased in popularity, particularly as a mechanism to improve exercise performance by modifying energetics. Since the skeletal muscle is a major metabolic and locomotory organ, it is important to take it into consideration when considering the effect of a dietary intervention, and the impact of physical activity on the body. The goal of this review is to summarize what is currently known and what still needs to be investigated concerning the relationship between ketone body metabolism and exercise, specifically in the skeletal muscle. Overall, it is clear that increased exposure to ketone bodies in combination with exercise can modify skeletal muscle metabolism, but whether this effect is beneficial or detrimental remains unclear and needs to be further interrogated before ketogenic diets or exogenous ketone supplementation can be recommended.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15194228