Beth Levine's Legacy: From the Discovery of BECN1 to Therapies. A Mentees' Perspective

With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multi...

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Published in:Frontiers in cell and developmental biology 2022-06, Vol.10, p.891332-891332
Main Authors: An, Zhenyi, Chiang, Wei-Chung, Fernández, Álvaro F, Franco, Luis H, He, CongCong, Huang, Shu-Yi, Lee, Eunmyong, Liu, Yang, Sebti, Salwa, Shoji-Kawata, Sanae, Sirasanagandla, Shyam, Wang, Richard C, Wei, Yongjie, Zhao, Yuting, Vega-Rubin-de-Celis, Silvia
Format: Article
Language:English
Subjects:
aging
BECN1
cancer
Cell and Developmental Biology
macroautophagy
metabolism
selective autophagy
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Summary:With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.891332