Severe aplastic anaemia after serial vaccinations for SARS‐CoV‐2, pneumococcus and seasonal influenza

We present a 67‐year‐old woman who developed progressive pancytopenia over 10 months, concomitant with administration of severe adult respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), pneumococcal and influenza vaccines. She developed mild leukopenia ∼2 weeks after the SARS‐CoV‐2 mRNA vaccine sequenc...

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Bibliographic Details
Published in:EJHaem 2022-08, Vol.3 (3), p.983-988
Main Authors: Wang, Xiao, Laczko, Dorottya, Caponetti, Gabriel C., Rabatin, Susan, Babushok, Daria V.
Format: Article
Language:English
Subjects:
Anemia
aplastic anaemia
Biopsy
Blood platelets
Blood tests
Bone marrow
Case Report
Case Reports
Coronaviruses
COVID-19
COVID-19 vaccines
Flow cytometry
Hemoglobin
Hepatitis B
immunization
Influenza
International organizations
Laboratories
Leukopenia
Lymphocytes
mRNA
mRNA vaccines
Neutrophils
Pancytopenia
paroxysmal nocturnal haemoglobinuria
SARS‐CoV‐2
Severe acute respiratory syndrome coronavirus 2
T cell receptors
Vaccines
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Summary:We present a 67‐year‐old woman who developed progressive pancytopenia over 10 months, concomitant with administration of severe adult respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), pneumococcal and influenza vaccines. She developed mild leukopenia ∼2 weeks after the SARS‐CoV‐2 mRNA vaccine sequence, with progressive symptoms after subsequent vaccines, eventually developing severe aplastic anaemia (SAA). While there have been several reports of vaccine‐related SAA, at time of submission, our case is the first reported to develop after the Moderna mRNA SARS‐CoV‐2 vaccine, as well as the first to document the gradual development of SAA over the course of many vaccine exposures. Physicians should be cognizant of vaccine‐associated SAA, considering current widespread coronavirus disease 2019 vaccination efforts.
ISSN:2688-6146
2688-6146
DOI:10.1002/jha2.443