Heat-Killed Lactococcus lactis subsp. cremoris H61 Altered the Iron Status of Young Women: A Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group Comparative Study

Women are prone to iron deficiency because of increased iron excretion associated with menstruation. This is often treated by oral iron supplementation, although this treatment can cause side effects, such as stomach pain and nausea, with low absorption of ingested iron. Previously, a significant in...

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Bibliographic Details
Published in:Nutrients 2022-07, Vol.14 (15), p.3144
Main Authors: Takaragawa, Mizuki, Sakuraba, Keishoku, Suzuki, Yoshio
Format: Article
Language:English
Subjects:
Absorption
Anemia
Blood & organ donations
Cellulose
Comparative studies
Dietary supplements
Ferritin
Food consumption
Generalized linear models
Heat
Ingestion
Iron
Lactococcus lactis
Menstruation
Nausea
Nutrient deficiency
Pain
Placebos
probiotics
Questionnaires
serum iron
Transferrin
transferrin saturation
Transferrins
unsaturated iron-binding capacity
Vitamin C
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Summary:Women are prone to iron deficiency because of increased iron excretion associated with menstruation. This is often treated by oral iron supplementation, although this treatment can cause side effects, such as stomach pain and nausea, with low absorption of ingested iron. Previously, a significant increase in serum iron was observed in association with the consumption of foods containing Lactococcus lactis subsp. cremoris H61 (H61). However, the causal relationship between H61 ingestion and elevated serum iron is still unclear. Therefore, in this study, we aimed to determine the effects of H61 ingestion on the iron status of young women. Healthy young Japanese women (18–25 years of age) ingested either heat-killed H61 or placebo for 4 weeks. Serum iron, transferrin saturation, and ferritin were significantly elevated in the H61 group but remained unchanged in the placebo group. Compared to before the intervention, iron intake remained unchanged during the intervention period, so the change in the iron status of the H61 group was not due to increased iron intake. These results suggest that heat-killed H61 may elevate iron status by enhancing iron absorption.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14153144