Association of transforming growth factor-β1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases

• Published in: Haematologica (Roma) 2007-11, Vol.92 (11), p.1470-1474
• Main Authors: HATTA, Kanako, MORIMOTO, Akira, ISHII, Ellchi, KIMURA, Hiroshi, UEDA, Ikuyo, HIBI, Shigeyoshi, TODO, Shinjiro, SUGIMOTO, Tohru, IMASHUKU, Shinsaku
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Hematologic and hematopoietic diseases; Medical sciences
• ISSN: 0390-6078; 1592-8721
• DOI: 10.3324/haematol.11147

Background and Objectives Epstein-Barr virus (EBV) is etiologically associated with various hematologic disorders, including primary acute infectious mononucleosis (IM), hemophagocytic lymphohistiocytosis (EBV-HLH), chronic active EBV infection (CAEBV) and malignant lymphomas. Although cytokines play a central role in EBV-related immune responses, the exact mechanisms causing different clinical responses remain unclear. In this study, the pattern of cytokine gene polymorphisms was comparatively analyzed in EBV-related diseases.Design and Methods Eighty-nine patients with EBV-related disease were analyzed; 30 with IM, 28 with EBV-HLH and 31 with CAEBV. Eighty-one EBV-seropositive healthy adults were also used as controls. Associations with polymorphisms of various cytokines, including interleukin (IL)-1α and IL-1β were evaluated. The gene polymorphisms were typed by polymerase chain reaction with sequence-specific primers.Results A significant difference of polymorphisms was found for transforming growth factor (TGF)-β1; the frequency of TGF-β1 codon 10 C allele was significantly higher in patients with EBV-related diseases than in controls (p