Predictive value of bone turnover markers and thyroid indicators for bone metabolism in GD patients after treatment

• Published in: Frontiers in endocrinology (Lausanne) 2024-04, Vol.15, p.1301213-1301213
• Main Authors: Su, Mengxue, Chai, Jinyan, Zheng, Wei, Jia, Qiang, Tan, Jian, He, Yajing, Zhang, Ruiguo, Men, Jianlong, Liu, Wei, Shi, Tao, Ren, Jing, Dong, Liyan, Liu, Luyi, Meng, Zhaowei
• Format: Article
• Language: English
• Subjects: Adult; Antithyroid Agents - therapeutic use; Biomarkers - blood; Bone and Bones - metabolism; Bone Remodeling; bone turnover markers (BTMs); Case-Control Studies; CTX (C-terminal telopeptide of type 1 collagen); Endocrinology; Female; Follow-Up Studies; Graves Disease - blood; Graves Disease - drug therapy; Graves Disease - metabolism; Humans; hyperthyroid; Male; Middle Aged; osteocalcin; P1NP; Predictive Value of Tests; procollagen type 1 N-terminal propeptide; Prognosis; Retrospective Studies; Thyroid Gland - metabolism; Thyroid Hormones - blood; Thyroxine - blood; Triiodothyronine - blood
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2024.1301213

To investigate the relationship between bone turnover markers (BTMs) and thyroid indicators in Graves' disease (GD) and to further assess predictive value of changes in early stage retrospectively. We studied 435 patients with GD and 113 healthy physical examiners retrospectively and followed up these two groups of patients after 6 months. We investigated the correlations between BTMs and other 15 observed factors, and analyzed the predictive value of FT and FT before and after treatment (FT -P/FT -A, FT -P/FT -A) on whether BTMs recovered. The levels of thyroid hormones and BTMs in GD group were significantly higher than those in control group (P < 0.05) and decreased after 6 months of treatment. FT3, W, Ca and ALP were independent factors in predicting the elevation of OST. Duration of disease, FT3, TSH and ALP were independent factors in predicting the elevation of P1NP. Age, duration of disease, TRAb and ALP were independent factors in predicting the elevation of CTX-1. The AUC of FT -P/FT -A and FT -P/FT -A for predicting OST recovery were 0.748 and 0.705 (P < 0.05), respectively, and the cut-off values were 0.51 and 0.595. There was no predictive value for P1NP and CTX-1 recovery (P > 0.05). BTMs were abnormally elevated in GD and were significantly correlated with serum levels of FT3, FT4, TRAb, Ca, and ALP. FT decreased more than 51% and FT dropped more than 59.5% after 6 months of treatment were independent predictors for the recovery of BTMs in GD.