Intra-Amniotic Administration of Cashew Nut ( Anacardium occidentale L.) Soluble Extract Improved Gut Functionality and Morphology In Vivo ( Gallus gallus )

Cashew nuts are rich in dietary fibers, monounsaturated fatty acids, carotenoids, tocopherols, flavonoids, catechins, amino acids, and minerals that offer benefits for health. However, the knowledge of its effect on gut health is lacking. In this way, cashew nut soluble extract (CNSE) was assessed i...

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Published in:Nutrients 2023-05, Vol.15 (10), p.2378
Main Authors: Meneguelli, Talitha Silva, Kolba, Nikolai, Misra, Arundhati, Dionísio, Ana Paula, Pelissari Kravchychyn, Ana Claudia, Da Silva, Bárbara Pereira, Stampini Duarte Martino, Hercia, Hermsdorff, Helen Hermana Miranda, Tako, Elad
Format: Article
Language:English
Subjects:
Absorptivity
Aminopeptidase
Anacardium - chemistry
Anacardium occidentale L
Animals
Carotenoids
cashew nut
Catechin
Chickens
Crypts
Dietary fiber
Dietary minerals
Digestive system
Escherichia coli
Fatty acids
Fibers
Flavonoids
Gallus gallus
Gene expression
gut health
Injection
Intestinal microflora
Intestine
Microbiota
Microorganisms
Morphology
Nuts
Nuts - chemistry
Parameter modification
Phytochemicals
Plant Extracts - analysis
Plant Extracts - pharmacology
Prebiotics
Selenium
Small intestine
Tocopherols
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Summary:Cashew nuts are rich in dietary fibers, monounsaturated fatty acids, carotenoids, tocopherols, flavonoids, catechins, amino acids, and minerals that offer benefits for health. However, the knowledge of its effect on gut health is lacking. In this way, cashew nut soluble extract (CNSE) was assessed in vivo via intra-amniotic administration in intestinal brush border membrane (BBM) morphology, functionality, and gut microbiota. Four groups were evaluated: (1) no injection (control); (2) H O injection (control); (3) 10 mg/mL CNSE (1%); and (4) 50 mg/mL CNSE (5%). Results related to CNSE on duodenal morphological parameters showed higher Paneth cell numbers, goblet cell (GC) diameter in crypt and villi, depth crypt, mixed GC per villi, and villi surface area. Further, it decreased GC number and acid and neutral GC. In the gut microbiota, treatment with CNSE showed a lower abundance of , , and . Further, in intestinal functionality, CNSE upregulated aminopeptidase (AP) gene expression at 5% compared to 1% CNSE. In conclusion, CNSE had beneficial effects on gut health by improving duodenal BBM functionality, as it upregulated AP gene expression, and by modifying morphological parameters ameliorating digestive and absorptive capacity. For intestinal microbiota, higher concentrations of CNSE or long-term intervention may be necessary.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15102378