An ionizable lipid toolbox for RNA delivery

Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future devel...

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Bibliographic Details
Published in:Nature communications 2021-12, Vol.12 (1), p.7233-7233, Article 7233
Main Authors: Han, Xuexiang, Zhang, Hanwen, Butowska, Kamila, Swingle, Kelsey L., Alameh, Mohamad-Gabriel, Weissman, Drew, Mitchell, Michael J.
Format: Article
Language:English
Subjects:
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Comment
Drug Delivery Systems - instrumentation
Drug Development
Endosomes - drug effects
Humanities and Social Sciences
Humans
Ions - chemistry
Lipids
Lipids - administration & dosage
Lipids - chemistry
Lipids - pharmacology
multidisciplinary
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Ribonucleic acid
RNA
RNA - administration & dosage
RNA - chemistry
Science
Science (multidisciplinary)
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Summary:Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-021-27493-0