An ionizable lipid toolbox for RNA delivery

Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future devel...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications 2021-12, Vol.12 (1), p.7233-7233, Article 7233
Main Authors: Han, Xuexiang, Zhang, Hanwen, Butowska, Kamila, Swingle, Kelsey L., Alameh, Mohamad-Gabriel, Weissman, Drew, Mitchell, Michael J.
Format: Article
Language:English
Subjects:
42
42/109
42/44
631/154/152
631/61/391
639/301/54/992
Comment
Drug Delivery Systems - instrumentation
Drug Development
Endosomes - drug effects
Humanities and Social Sciences
Humans
Ions - chemistry
Lipids
Lipids - administration & dosage
Lipids - chemistry
Lipids - pharmacology
multidisciplinary
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Ribonucleic acid
RNA
RNA - administration & dosage
RNA - chemistry
Science
Science (multidisciplinary)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c540t-7fdd8a878d4361222ffbcab962f9be4a926bc245b5ed222d2be209e7cd8bf5ff3
cites cdi_FETCH-LOGICAL-c540t-7fdd8a878d4361222ffbcab962f9be4a926bc245b5ed222d2be209e7cd8bf5ff3
container_end_page 7233
container_issue 1
container_start_page 7233
container_title Nature communications
container_volume 12
creator Han, Xuexiang
Zhang, Hanwen
Butowska, Kamila
Swingle, Kelsey L.
Alameh, Mohamad-Gabriel
Weissman, Drew
Mitchell, Michael J.
description Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.
doi_str_mv 10.1038/s41467-021-27493-0
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_2078c7804ee7479387552ef0bdd9efde</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_2078c7804ee7479387552ef0bdd9efde</doaj_id><sourcerecordid>2610079314</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-7fdd8a878d4361222ffbcab962f9be4a926bc245b5ed222d2be209e7cd8bf5ff3</originalsourceid><addsrcrecordid>eNp9kUtrFTEYhoMottT-ARcy4EaQqblOko1wKF4KRUF0HXL5csxhzuSYzCmtv960U3txYTYJ-Z48X5IXoZcEnxDM1LvKCR9kjynpqeSa9fgJOqSYk55Iyp4-WB-g41o3uA2mieL8OTpgXGMmOTlEb1dTl_KUfls3QjemXQrdnPPo8mUXc-m-fVl1AcZ0AeXqBXoW7Vjh-HY-Qj8-fvh--rk___rp7HR13nvB8dzLGIKySqrA2UAopTE6b50eaNQOuNV0cJ5y4QSEVg3UAcUapA_KRREjO0JnizdkuzG7kra2XJlsk7nZyGVtbJmTH8FQLJWXCnMAyaVmSgpBIWIXgoYYoLneL67d3m0heJjmYsdH0seVKf0063xh1DAojUkTvLkVlPxrD3U221Q9jKOdIO-roQPBuHUmvKGv_0E3eV-m9lWNwlpQIQRuFF0oX3KtBeLdZQg219GaJVrTojU30ZrrQ68ePuPuyN8gG8AWoLbStIZy3_s_2j-wNK3C</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2609525550</pqid></control><display><type>article</type><title>An ionizable lipid toolbox for RNA delivery</title><source>Nature_系列刊</source><source>Publicly Available Content Database</source><source>PubMed Central</source><source>Coronavirus Research Database</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Han, Xuexiang ; Zhang, Hanwen ; Butowska, Kamila ; Swingle, Kelsey L. ; Alameh, Mohamad-Gabriel ; Weissman, Drew ; Mitchell, Michael J.</creator><creatorcontrib>Han, Xuexiang ; Zhang, Hanwen ; Butowska, Kamila ; Swingle, Kelsey L. ; Alameh, Mohamad-Gabriel ; Weissman, Drew ; Mitchell, Michael J.</creatorcontrib><description>Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/s41467-021-27493-0</identifier><identifier>PMID: 34903741</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>42 ; 42/109 ; 42/44 ; 631/154/152 ; 631/61/391 ; 639/301/54/992 ; Comment ; Drug Delivery Systems - instrumentation ; Drug Development ; Endosomes - drug effects ; Humanities and Social Sciences ; Humans ; Ions - chemistry ; Lipids ; Lipids - administration &amp; dosage ; Lipids - chemistry ; Lipids - pharmacology ; multidisciplinary ; Nanoparticles ; Nanoparticles - administration &amp; dosage ; Nanoparticles - chemistry ; Ribonucleic acid ; RNA ; RNA - administration &amp; dosage ; RNA - chemistry ; Science ; Science (multidisciplinary)</subject><ispartof>Nature communications, 2021-12, Vol.12 (1), p.7233-7233, Article 7233</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-7fdd8a878d4361222ffbcab962f9be4a926bc245b5ed222d2be209e7cd8bf5ff3</citedby><cites>FETCH-LOGICAL-c540t-7fdd8a878d4361222ffbcab962f9be4a926bc245b5ed222d2be209e7cd8bf5ff3</cites><orcidid>0000-0001-8475-9206 ; 0000-0002-5672-6930 ; 0000-0002-3628-2244</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2609525550/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2609525550?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793,74284,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34903741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Xuexiang</creatorcontrib><creatorcontrib>Zhang, Hanwen</creatorcontrib><creatorcontrib>Butowska, Kamila</creatorcontrib><creatorcontrib>Swingle, Kelsey L.</creatorcontrib><creatorcontrib>Alameh, Mohamad-Gabriel</creatorcontrib><creatorcontrib>Weissman, Drew</creatorcontrib><creatorcontrib>Mitchell, Michael J.</creatorcontrib><title>An ionizable lipid toolbox for RNA delivery</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.</description><subject>42</subject><subject>42/109</subject><subject>42/44</subject><subject>631/154/152</subject><subject>631/61/391</subject><subject>639/301/54/992</subject><subject>Comment</subject><subject>Drug Delivery Systems - instrumentation</subject><subject>Drug Development</subject><subject>Endosomes - drug effects</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Ions - chemistry</subject><subject>Lipids</subject><subject>Lipids - administration &amp; dosage</subject><subject>Lipids - chemistry</subject><subject>Lipids - pharmacology</subject><subject>multidisciplinary</subject><subject>Nanoparticles</subject><subject>Nanoparticles - administration &amp; dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA - administration &amp; dosage</subject><subject>RNA - chemistry</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kUtrFTEYhoMottT-ARcy4EaQqblOko1wKF4KRUF0HXL5csxhzuSYzCmtv960U3txYTYJ-Z48X5IXoZcEnxDM1LvKCR9kjynpqeSa9fgJOqSYk55Iyp4-WB-g41o3uA2mieL8OTpgXGMmOTlEb1dTl_KUfls3QjemXQrdnPPo8mUXc-m-fVl1AcZ0AeXqBXoW7Vjh-HY-Qj8-fvh--rk___rp7HR13nvB8dzLGIKySqrA2UAopTE6b50eaNQOuNV0cJ5y4QSEVg3UAcUapA_KRREjO0JnizdkuzG7kra2XJlsk7nZyGVtbJmTH8FQLJWXCnMAyaVmSgpBIWIXgoYYoLneL67d3m0heJjmYsdH0seVKf0063xh1DAojUkTvLkVlPxrD3U221Q9jKOdIO-roQPBuHUmvKGv_0E3eV-m9lWNwlpQIQRuFF0oX3KtBeLdZQg219GaJVrTojU30ZrrQ68ePuPuyN8gG8AWoLbStIZy3_s_2j-wNK3C</recordid><startdate>20211213</startdate><enddate>20211213</enddate><creator>Han, Xuexiang</creator><creator>Zhang, Hanwen</creator><creator>Butowska, Kamila</creator><creator>Swingle, Kelsey L.</creator><creator>Alameh, Mohamad-Gabriel</creator><creator>Weissman, Drew</creator><creator>Mitchell, Michael J.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8475-9206</orcidid><orcidid>https://orcid.org/0000-0002-5672-6930</orcidid><orcidid>https://orcid.org/0000-0002-3628-2244</orcidid></search><sort><creationdate>20211213</creationdate><title>An ionizable lipid toolbox for RNA delivery</title><author>Han, Xuexiang ; Zhang, Hanwen ; Butowska, Kamila ; Swingle, Kelsey L. ; Alameh, Mohamad-Gabriel ; Weissman, Drew ; Mitchell, Michael J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-7fdd8a878d4361222ffbcab962f9be4a926bc245b5ed222d2be209e7cd8bf5ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>42</topic><topic>42/109</topic><topic>42/44</topic><topic>631/154/152</topic><topic>631/61/391</topic><topic>639/301/54/992</topic><topic>Comment</topic><topic>Drug Delivery Systems - instrumentation</topic><topic>Drug Development</topic><topic>Endosomes - drug effects</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Ions - chemistry</topic><topic>Lipids</topic><topic>Lipids - administration &amp; dosage</topic><topic>Lipids - chemistry</topic><topic>Lipids - pharmacology</topic><topic>multidisciplinary</topic><topic>Nanoparticles</topic><topic>Nanoparticles - administration &amp; dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA - administration &amp; dosage</topic><topic>RNA - chemistry</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Xuexiang</creatorcontrib><creatorcontrib>Zhang, Hanwen</creatorcontrib><creatorcontrib>Butowska, Kamila</creatorcontrib><creatorcontrib>Swingle, Kelsey L.</creatorcontrib><creatorcontrib>Alameh, Mohamad-Gabriel</creatorcontrib><creatorcontrib>Weissman, Drew</creatorcontrib><creatorcontrib>Mitchell, Michael J.</creatorcontrib><collection>Springer_OA刊</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Xuexiang</au><au>Zhang, Hanwen</au><au>Butowska, Kamila</au><au>Swingle, Kelsey L.</au><au>Alameh, Mohamad-Gabriel</au><au>Weissman, Drew</au><au>Mitchell, Michael J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An ionizable lipid toolbox for RNA delivery</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2021-12-13</date><risdate>2021</risdate><volume>12</volume><issue>1</issue><spage>7233</spage><epage>7233</epage><pages>7233-7233</pages><artnum>7233</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34903741</pmid><doi>10.1038/s41467-021-27493-0</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8475-9206</orcidid><orcidid>https://orcid.org/0000-0002-5672-6930</orcidid><orcidid>https://orcid.org/0000-0002-3628-2244</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2041-1723
ispartof Nature communications, 2021-12, Vol.12 (1), p.7233-7233, Article 7233
issn 2041-1723
2041-1723
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_2078c7804ee7479387552ef0bdd9efde
source Nature_系列刊; Publicly Available Content Database; PubMed Central; Coronavirus Research Database; Springer Nature - nature.com Journals - Fully Open Access
subjects 42
42/109
42/44
631/154/152
631/61/391
639/301/54/992
Comment
Drug Delivery Systems - instrumentation
Drug Development
Endosomes - drug effects
Humanities and Social Sciences
Humans
Ions - chemistry
Lipids
Lipids - administration & dosage
Lipids - chemistry
Lipids - pharmacology
multidisciplinary
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Ribonucleic acid
RNA
RNA - administration & dosage
RNA - chemistry
Science
Science (multidisciplinary)
title An ionizable lipid toolbox for RNA delivery
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T04%3A37%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20ionizable%20lipid%20toolbox%20for%20RNA%20delivery&rft.jtitle=Nature%20communications&rft.au=Han,%20Xuexiang&rft.date=2021-12-13&rft.volume=12&rft.issue=1&rft.spage=7233&rft.epage=7233&rft.pages=7233-7233&rft.artnum=7233&rft.issn=2041-1723&rft.eissn=2041-1723&rft_id=info:doi/10.1038/s41467-021-27493-0&rft_dat=%3Cproquest_doaj_%3E2610079314%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c540t-7fdd8a878d4361222ffbcab962f9be4a926bc245b5ed222d2be209e7cd8bf5ff3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2609525550&rft_id=info:pmid/34903741&rfr_iscdi=true