Cardiac effects and clinical applications of MG53

Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell mem...

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Bibliographic Details
Published in:Cell & bioscience 2021-06, Vol.11 (1), p.115-115, Article 115
Main Authors: Zhong, Weina, Benissan-Messan, Dathe Z, Ma, Jianjie, Cai, Chuanxi, Lee, Peter H U
Format: Article
Language:English
Subjects:
Apoptosis
Cardiomyocytes
Cardiomyopathy
Cardioprotection
Cell membranes
Coronary artery disease
Diabetes
Diabetes mellitus
Fibrosis
Heart
Heart disease
Heart diseases
Hypoxia
Ischemia
Kinases
Membrane repair
MG53
Muscles
Musculoskeletal system
Myogenesis
Oxidative stress
Phosphorylation
Plasma
Potassium
Proteins
Reperfusion
Review
Skeletal muscle
Therapeutic applications
Tumor necrosis factor-TNF
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Summary:Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell membrane repair and primarily found in striated muscle. Its role in skeletal muscle regeneration and myogenesis has been well documented. However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. This review summarizes the regulatory role of MG53 in cardiac tissues, current debates regarding MG53 in diabetes and diabetic cardiomyopathy, as well as highlights potential clinical applications of MG53 in treating cardiac pathologies.
ISSN:2045-3701
2045-3701
DOI:10.1186/s13578-021-00629-x