Lung injury induced by different negative suction pressure in patients with pneumoconiosis undergoing whole lung lavage

Pneumoconiosis is a diffuse interstitial fibronodular lung disease, which is caused by the inhalation of crystalline silica. Whole lung lavage (WLL) is a therapeutic procedure used to treat pneumoconiosis. This study is to compare the effects of different negative pressure suction on lung injury in...

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Bibliographic Details
Published in:BMC pulmonary medicine 2022-04, Vol.22 (1), p.152-152, Article 152
Main Authors: Yang, Mingyuan, Li, Baoping, Wang, Bin, Li, Lei, Ji, Yurong, Zhou, Yunzhi, Huang, Rui, Cheng, Qinghao
Format: Article
Language:English
Subjects:
Analysis
Anesthesia
Blood gases
Blood pressure
Bronchoalveolar Lavage
Carbon dioxide
Carbon monoxide
Care and treatment
Cytokines
Diagnosis
Health aspects
Humans
Inflammation
Inhalation
Interleukin 10
Interleukins
Lactic acid
Lavage
Lung
Lung diseases
Lung Diseases, Interstitial
Lung Injury
Lungs
Methods
Negative suction pressure
Oxidative stress
Patient outcomes
Patients
Pneumoconiosis
Pneumoconiosis - therapy
Prospective Studies
Pulmonology
Respiratory function
Risk factors
Silica
Statistical analysis
Statistics
Suction
Suctioning
Superoxide Dismutase
Tumor necrosis factor-TNF
Variance analysis
Whole lung lavage
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Summary:Pneumoconiosis is a diffuse interstitial fibronodular lung disease, which is caused by the inhalation of crystalline silica. Whole lung lavage (WLL) is a therapeutic procedure used to treat pneumoconiosis. This study is to compare the effects of different negative pressure suction on lung injury in patients with pneumoconiosis undergoing WLL. A prospective study was conducted with 24 consecutively pneumoconiosis patients who underwent WLL from March 2020 to July 2020 at Emergency General Hospital, China. The patients were divided into two groups: high negative suction pressure group (group H, n = 13, negative suction pressure of 300-400 mmHg) and low negative suction pressure group (group L, n = 11, negative suction pressure of 40-50 mmHg). The arterial blood gas, lung function, lavage data, oxidative stress, and inflammatory responses to access lung injury were monitored. Compared with those of group H, the right and left lung residual were significantly increased in the group L (P = 0.04, P = 0.01). Potential of hydrogen (pH), arterial partial pressure of oxygen (PaO ), arterial partial pressure of carbon dioxide (PaCO ), lactic acid (LAC) and glucose (GLU) varied from point to point in time (P 
ISSN:1471-2466
1471-2466
DOI:10.1186/s12890-022-01952-w