Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance

Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear...

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Bibliographic Details
Published in:Molecular brain 2011-06, Vol.4 (1), p.26-26, Article 26
Main Authors: Hasbi, Ahmed, O'Dowd, Brian F, George, Susan R
Format: Article
Language:English
Subjects:
Addictions
Addictive behaviors
Amphetamines
Animals
Artificial chromosomes
Attention Deficit Hyperactivity Disorder
Behavior
Brain - physiology
Brain research
Cellular signal transduction
Cloning
Dopamine
Dopamine receptors
Genetic aspects
Humans
Kinases
Mental health
Neurons
Neurosciences
Physiological aspects
Proteins
Receptors, Dopamine D1 - metabolism
Receptors, Dopamine D2 - metabolism
Review
Rodents
Schizophrenia
Signal Transduction
Studies
Substance abuse treatment
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Summary:Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance.
ISSN:1756-6606
1756-6606
DOI:10.1186/1756-6606-4-26