Dietary flavanones and citrus fruits influence cytokines and thyroid transcription factor-1 in an HDM-induced chronic asthma murine model

•Citrus fruit or flavanone effects on airway remodelling features are little known.•Their effects on asthma pro-inflammatory and transcription factors are evaluated.•Grapefruit-orange or hesperetin–naringenin reduced TNF-α and TGF-β expression.•Mixed intake of them may have synergic activities and m...

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Bibliographic Details
Published in:Journal of functional foods 2016-10, Vol.26, p.709-718
Main Authors: Seyedrezazadeh, Ensiyeh, Sabri, Amin, Barzegari, Abolfazl, Kolahian, Saeed, Shahbazfar, Amir-Ali, Ansarin, Khalil, Vafa, Mohammadreza, Sakhinia, Ebrahim
Format: Article
Language:English
Subjects:
Asthma
Citrus fruit
Cytokines
Flavanones
Thyroid transcription factor-1
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Summary:•Citrus fruit or flavanone effects on airway remodelling features are little known.•Their effects on asthma pro-inflammatory and transcription factors are evaluated.•Grapefruit-orange or hesperetin–naringenin reduced TNF-α and TGF-β expression.•Mixed intake of them may have synergic activities and may ameliorate airway remodelling. The effects of hesperetin plus naringenin, orange juice and grapefruit juice on mRNA expression of TNF-α, TGF-β1 and TTF-1 in a house dust mite (HDM)-induced asthma animal model were investigated. Interventional mice exposed to HDM for 6 weeks received hesperetin plus naringenin, orange plus grapefruit juice, orange juice, grapefruit juice or water during the last 4 weeks, whereas non-asthmatic control mice consumed water. Lung tissue TNF-α and TGF-β1 expressions in supplemented groups were significantly reduced (p 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2016.08.033