Moderate Fever Cycles as a Potential Mechanism to Protect the Respiratory System in COVID-19 Patients

Mortality in COVID-19 patients predominantly results from an acute respiratory distress syndrome (ARDS), in which lungs alveolar cells undergo programmed cell death. Mortality in a sepsis-induced ARDS rat model is reduced by adenovirus over-expression of the HSP70 chaperone. A natural rise of body t...

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Bibliographic Details
Published in:Frontiers in medicine 2020-09, Vol.7, p.564170-564170
Main Authors: Guihur, Anthony, Rebeaud, Mathieu E, Fauvet, Bruno, Tiwari, Satyam, Weiss, Yoram G, Goloubinoff, Pierre
Format: Article
Language:English
Subjects:
acute respiratory distress syndrome
COVID-19
fever
heat- shock response
Hsp70
Medicine
SARS-CoV-2
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Summary:Mortality in COVID-19 patients predominantly results from an acute respiratory distress syndrome (ARDS), in which lungs alveolar cells undergo programmed cell death. Mortality in a sepsis-induced ARDS rat model is reduced by adenovirus over-expression of the HSP70 chaperone. A natural rise of body temperature during mild fever can naturally accumulate high cellular levels of HSP70 that can arrest apoptosis and protect alveolar lung cells from inflammatory damages. However, beyond 1-2 h of fever, no HSP70 is being further produced and a decreased in body temperature required to the restore cell's ability to produce more HSP70 in a subsequent fever cycle. We suggest that antipyretics may be beneficial in COVID-19 patients subsequent to several hours of mild (
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2020.564170