Effect of surgical treatment for anorectal melanoma: a propensity score-matched analysis of the Surveillance, Epidemiology, and End Results programme data

ObjectiveAnorectal melanoma (AM) is a rare but aggressive tumour with limited information in the existing literature. This study aimed to assess the effect of surgical treatment for AM and predict the prognosis of affected patients.DesignA retrospective cohort study.SettingData of patients diagnosed...

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Bibliographic Details
Published in:BMJ open 2022-04, Vol.12 (4), p.e053339-e053339
Main Authors: Lei, Xiao, Qingqing, Luo, Weijie, Yuan, Li, Peng, Huang, Changhao, Kexun, Yu, Zihua, Chen
Format: Article
Language:English
Subjects:
Age
anorectal melanoma
Codes
Disease
Epidemiology
Hospitals
Humans
Medical prognosis
Melanoma
Melanoma - epidemiology
Melanoma - surgery
nomogram
Nomograms
overall survival
Patients
Prognosis
Propensity Score
Retrospective Studies
SEER Program
Software
Surgery
Surveillance
surveillance, epidemiology, and end results
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Summary:ObjectiveAnorectal melanoma (AM) is a rare but aggressive tumour with limited information in the existing literature. This study aimed to assess the effect of surgical treatment for AM and predict the prognosis of affected patients.DesignA retrospective cohort study.SettingData of patients diagnosed with AM between 1975 and 2016 in the USA were collected from the Surveillance, Epidemiology, and End Results (SEER) database.ParticipantsThis study enrolled a total of 795 patients with AM from the SEER database and the validation cohort comprised 40 patients with AM enrolled from Chinese institutes.Primary and secondary outcome measuresOverall survival (OS) and AM-specific survival (AM-SS).ResultsA total of 795 patients with AM diagnosed between 1975 and 2016 were enrolled in this study. Data over the past four decades showed a trend of increase in incidence rate. A nomogram based on a multivariate Cox regression model was generated to predict AM-SS. The C-index of the nomogram was 0.74 (95% CI 0.71 to 0.77) on internal verification. In the validation cohort, the C-index of the nomogram was 0.72 (95% CI 0.68 to 0.76). The results of propensity score matching (PSM) analysis showed that patients who underwent surgical treatment achieved significant survival (OS: log-rank=17.41, p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2021-053339