Nodal Melanoma Metastasis under Infliximab Therapy in a Patient with Nevoid Melanoma First Misdiagnosed as Benign Nevus: A Potentially Dangerous Diagnostic Pitfall in the Era of Biologic Therapies

We report the case of a 53-year-old Caucasian woman who developed nodal melanoma metastasis under infliximab therapy 2 years after the removal of a nevoid melanoma, which was initially misdiagnosed as a benign compound nevus. This case illustrates the potential link between tumor necrosis factor (TN...

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Bibliographic Details
Published in:Case reports in dermatology 2013-10, Vol.5 (3), p.290-294
Main Authors: Safa, Gilles, Fromentoux, Sophie, Darrieux, Laure, Hogenhuis, Jean-Anastase, Tisseau, Laurent
Format: Article
Language:English
Subjects:
Diagnostic pitfalls
Infliximab
Metastasis
Nevoid melanoma
Published: October 2013
Tumor necrosis factor-α
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Summary:We report the case of a 53-year-old Caucasian woman who developed nodal melanoma metastasis under infliximab therapy 2 years after the removal of a nevoid melanoma, which was initially misdiagnosed as a benign compound nevus. This case illustrates the potential link between tumor necrosis factor (TNF)-α inhibition and the reactivation of latent melanoma. Furthermore, this case highlights the need for a complete skin examination before using anti-TNF-α therapy to rule out atypical malignant lesions or melanomas that can easily be missed because of presentations such as nevoid melanoma.
ISSN:1662-6567
1662-6567
DOI:10.1159/000355670