Clinicopathologic characteristics and prognosis for male breast cancer compared to female breast cancer

• Published in: Scientific reports 2022-01, Vol.12 (1), p.220-220, Article 220
• Main Authors: Yao, Nan, Shi, Wenzai, Liu, Tong, Siyin, Sarah Tan, Wang, Weiqi, Duan, Ning, Xu, Guoshuai, Qu, Jun
• Format: Article
• Language: English
• Subjects: 631/67; 692/4028; 692/699; Adult; Aged; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Breast Neoplasms, Male - genetics; Breast Neoplasms, Male - mortality; Breast Neoplasms, Male - pathology; Cohort Studies; Epidemiology; Epidermal growth factor; ErbB-2 protein; Estrogen receptors; Estrogens; Female; Females; Humanities and Social Sciences; Humans; Male; Medical prognosis; Mens health; Middle Aged; multidisciplinary; Patients; Population studies; Progesterone; Prognosis; Proportional Hazards Models; Receptor, ErbB-2 - genetics; Receptors, Estrogen - genetics; Receptors, Progesterone - genetics; Regression analysis; Retrospective Studies; Risk factors; Science; Science (multidisciplinary); Survival; Tumors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-04342-0

Male breast cancer (MBC) is rare. Due to limited information, MBC has always been understudied. We conducted a retrospective population-based cohort study using data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program. The clinical and biological features of female breast cancer (FBC) patients were compared with MBC patients. Cox regression models and competing risks analyses were used to identify risk factors associated with cancer-related survival in MBC and FBC groups. Results showed that MBC patients suffered from higher TNM stages, tumor grades, and a higher percentage of hormone receptor-positive tumors, compared with FBC patients (all p