The relationship between stress and Alzheimer's disease

Stress is critically involved in the development and progression of disease. From the stress of undergoing treatments to facing your own mortality, the physiological processes that stress drives have a serious detrimental effect on the ability to heal, cope and maintain a positive quality of life. T...

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Bibliographic Details
Published in:Neurobiology of stress 2018-02, Vol.8, p.127-133
Main Author: Justice, Nicholas J.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Corticosteroids
Cortisol
CRF
CRH
from the Special Issue on "Stress and the Pathogenesis of Alzheimer’s Disease"
Edited by Hongxin Dong, John Csernansky
Stress
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Summary:Stress is critically involved in the development and progression of disease. From the stress of undergoing treatments to facing your own mortality, the physiological processes that stress drives have a serious detrimental effect on the ability to heal, cope and maintain a positive quality of life. This is becoming increasingly clear in the case of neurodegenerative diseases. Neurodegenerative diseases involve the devastating loss of cognitive and motor function which is stressful in itself, but can also disrupt neural circuits that mediate stress responses. Disrupting these circuits produces aberrant emotional and aggressive behavior that causes long-term care to be especially difficult. In addition, added stress drives progression of the disease and can exacerbate symptoms. In this review, I describe how neural and endocrine pathways activated by stress interact with ongoing neurodegenerative disease from both a clinical and experimental perspective.
ISSN:2352-2895
2352-2895
DOI:10.1016/j.ynstr.2018.04.002