Epigenetics in obesity: Mechanisms and advances in therapies based on natural products

Obesity is a major risk factor for morbidity and mortality because it has a close relationship to metabolic illnesses, such as diabetes, cardiovascular diseases, and some types of cancer. With no drugs available, the mainstay of obesity management remains lifestyle changes with exercise and dietary...

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Published in:Pharmacology research & perspectives 2024-02, Vol.12 (1), p.e1171-n/a
Main Authors: Chen, Peng, Wang, Yulai, Chen, Fuchao, Zhou, Benhong
Format: Article
Language:English
Subjects:
Advertising
Body fat
Body mass index
Disease
DNA methylation
Energy
Epigenetics
Expenditures
Families & family life
Family medical history
Fast food
Lifestyles
Metabolism
Metabolites
Microbiota
MicroRNAs
Natural products
Obesity
Overweight
Review
Reviews
targets
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Summary:Obesity is a major risk factor for morbidity and mortality because it has a close relationship to metabolic illnesses, such as diabetes, cardiovascular diseases, and some types of cancer. With no drugs available, the mainstay of obesity management remains lifestyle changes with exercise and dietary modifications. In light of the tremendous disease burden and unmet therapeutics, fresh perspectives on pathophysiology and drug discovery are needed. The development of epigenetics provides a compelling justification for how environmental, lifestyle, and other risk factors contribute to the pathogenesis of obesity. Furthermore, epigenetic dysregulations can be restored, and it has been reported that certain natural products obtained from plants, such as tea polyphenols, ellagic acid, urolithins, curcumin, genistein, isothiocyanates, and citrus isoflavonoids, were shown to inhibit weight gain. These substances have great antioxidant potential and are of great interest because they can also modify epigenetic mechanisms. Therefore, understanding epigenetic modifications to target the primary cause of obesity and the epigenetic mechanisms of anti‐obesity effects with certain phytochemicals can prove rational strategies to prevent the disease and develop novel therapeutic interventions. Thus, the current review aimed to summarize the epigenetic mechanisms and advances in therapies for obesity based on natural products to provide evidence for the development of several potential anti‐obesity drug targets. XXXX
ISSN:2052-1707
2052-1707
DOI:10.1002/prp2.1171