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Gene Expression Behavior of a Set of Genes in Platelet and Tissue Samples from Patients with Breast Cancer
The tumor microenvironment (TME) is constituted by a great diversity of highly dynamic cell populations, each of which contributes ligands, receptors, soluble proteins, mRNAs, and miRNAs, in order to regulate cellular activities within the TME and even promote processes such as angiogenesis or metas...
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| Published in: | International journal of molecular sciences 2023-05, Vol.24 (9), p.8348 |
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| container_issue | 9 |
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| container_title | International journal of molecular sciences |
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| creator | Burciaga-Hernandez, Luis A Cueto-Villalobos, Cecilia F Ortega-Piñon, Nancy Gonzalez-Curiel, Irma E Godina-Gonzalez, Susana Mendez-Frausto, Gwendolyne Aguilar-Esquivel, Anna P Maldonado-Lagunas, Vilma Guerrero-de la Torre, Luis E Melendez-Zajgla, Jorge Sanchez-Garcia, Erika K Mitre-Aguilar, Irma B Mendoza-Almanza, Gretel |
| description | The tumor microenvironment (TME) is constituted by a great diversity of highly dynamic cell populations, each of which contributes ligands, receptors, soluble proteins, mRNAs, and miRNAs, in order to regulate cellular activities within the TME and even promote processes such as angiogenesis or metastasis. Intravasated platelets (PLT) undergo changes in the TME that convert them into tumor-educated platelets (TEP), which supports the development of cancer, angiogenesis, and metastasis through the degranulation and release of biomolecules. Several authors have reported that the deregulation of
,
,
,
,
,
,
, and
genes participates in breast cancer progression, angiogenesis, and metastasis. The present work aimed to analyze the expression levels of this set of genes in tumor tissues and platelets derived from breast cancer patients by reverse transcription-quantitative polymerase chain reaction (RTqPCR) assays, in order to determine if there was an expression correlation between these sources and to take advantage of the new information to be used in possible diagnosis by liquid biopsy. Data from these assays showed that platelets and breast cancer tumors present similar expression levels of a subset of these genes' mRNAs, depending on the molecular subtype, comorbidities, and metastasis presence. |
| doi_str_mv | 10.3390/ijms24098348 |
| format | article |
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,
,
,
,
,
,
, and
genes participates in breast cancer progression, angiogenesis, and metastasis. The present work aimed to analyze the expression levels of this set of genes in tumor tissues and platelets derived from breast cancer patients by reverse transcription-quantitative polymerase chain reaction (RTqPCR) assays, in order to determine if there was an expression correlation between these sources and to take advantage of the new information to be used in possible diagnosis by liquid biopsy. Data from these assays showed that platelets and breast cancer tumors present similar expression levels of a subset of these genes' mRNAs, depending on the molecular subtype, comorbidities, and metastasis presence.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24098348</identifier><identifier>PMID: 37176055</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Analysis ; Angiogenesis ; biomarkers panel ; Biomolecules ; Biopsy ; Blood Platelets - metabolism ; Breast cancer ; Breast Neoplasms - metabolism ; Cancer ; Comorbidity ; Degranulation ; Deregulation ; Development and progression ; Disease ; Female ; Fibroblasts ; Gene Expression ; gene overexpression ; Genes ; Genetic aspects ; Genetic transcription ; Humans ; Membrane Proteins - metabolism ; Metastases ; Metastasis ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Oncogene Proteins - genetics ; Platelet-derived growth factor ; Polymerase chain reaction ; Reverse transcription ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Tumor microenvironment ; Tumor Microenvironment - genetics ; tumor-educated platelets ; Tumors ; variation in mRNA levels ; Vascular endothelial growth factor ; Wiskott-Aldrich Syndrome Protein Family - metabolism</subject><ispartof>International journal of molecular sciences, 2023-05, Vol.24 (9), p.8348</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c503t-a01fa1ec3f69976852972096619dd3733e301d43641519923d35a1fae598d3713</cites><orcidid>0000-0003-0340-9381 ; 0000-0002-7254-5961 ; 0000-0002-0044-9196 ; 0000-0001-6955-9003 ; 0000-0002-2209-1607 ; 0000-0002-3277-2203 ; 0000-0002-0426-7410 ; 0000-0001-9668-1127</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2812605682?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2812605682?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793,74412,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37176055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burciaga-Hernandez, Luis A</creatorcontrib><creatorcontrib>Cueto-Villalobos, Cecilia F</creatorcontrib><creatorcontrib>Ortega-Piñon, Nancy</creatorcontrib><creatorcontrib>Gonzalez-Curiel, Irma E</creatorcontrib><creatorcontrib>Godina-Gonzalez, Susana</creatorcontrib><creatorcontrib>Mendez-Frausto, Gwendolyne</creatorcontrib><creatorcontrib>Aguilar-Esquivel, Anna P</creatorcontrib><creatorcontrib>Maldonado-Lagunas, Vilma</creatorcontrib><creatorcontrib>Guerrero-de la Torre, Luis E</creatorcontrib><creatorcontrib>Melendez-Zajgla, Jorge</creatorcontrib><creatorcontrib>Sanchez-Garcia, Erika K</creatorcontrib><creatorcontrib>Mitre-Aguilar, Irma B</creatorcontrib><creatorcontrib>Mendoza-Almanza, Gretel</creatorcontrib><title>Gene Expression Behavior of a Set of Genes in Platelet and Tissue Samples from Patients with Breast Cancer</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The tumor microenvironment (TME) is constituted by a great diversity of highly dynamic cell populations, each of which contributes ligands, receptors, soluble proteins, mRNAs, and miRNAs, in order to regulate cellular activities within the TME and even promote processes such as angiogenesis or metastasis. Intravasated platelets (PLT) undergo changes in the TME that convert them into tumor-educated platelets (TEP), which supports the development of cancer, angiogenesis, and metastasis through the degranulation and release of biomolecules. Several authors have reported that the deregulation of
,
,
,
,
,
,
, and
genes participates in breast cancer progression, angiogenesis, and metastasis. The present work aimed to analyze the expression levels of this set of genes in tumor tissues and platelets derived from breast cancer patients by reverse transcription-quantitative polymerase chain reaction (RTqPCR) assays, in order to determine if there was an expression correlation between these sources and to take advantage of the new information to be used in possible diagnosis by liquid biopsy. Data from these assays showed that platelets and breast cancer tumors present similar expression levels of a subset of these genes' mRNAs, depending on the molecular subtype, comorbidities, and metastasis presence.</description><subject>Age</subject><subject>Analysis</subject><subject>Angiogenesis</subject><subject>biomarkers panel</subject><subject>Biomolecules</subject><subject>Biopsy</subject><subject>Blood Platelets - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cancer</subject><subject>Comorbidity</subject><subject>Degranulation</subject><subject>Deregulation</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Female</subject><subject>Fibroblasts</subject><subject>Gene Expression</subject><subject>gene overexpression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic transcription</subject><subject>Humans</subject><subject>Membrane Proteins - metabolism</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Oncogene Proteins - genetics</subject><subject>Platelet-derived growth factor</subject><subject>Polymerase chain reaction</subject><subject>Reverse transcription</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Tumor microenvironment</subject><subject>Tumor Microenvironment - genetics</subject><subject>tumor-educated platelets</subject><subject>Tumors</subject><subject>variation in mRNA levels</subject><subject>Vascular endothelial growth factor</subject><subject>Wiskott-Aldrich Syndrome Protein Family - metabolism</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptklFv1DAMxysEYtvBG88oEi88cCOJm7Z5QttpG5MmMWnjOcqlzl1ObXIk7YBvT8qNcYdQHmzZP_8tOy6KN4yeAkj60W36xEsqGyibZ8UxKzmfU1rVz_f8o-IkpQ2lHLiQL4sjqFldUSGOi80VeiQXP7YRU3LBk3Nc6wcXIgmWaHKHw-RMUCLOk9tOD9jloPYtuXcpjUjudL_tctrG0JNbPTj0QyLf3bAm5xF1GshCe4PxVfHC6i7h60c7K75eXtwvPs9vvlxdL85u5kZQGOaaMqsZGrCVlHXVCC5rTmVVMdm2UAMgUNaWUJVMMCk5tCB0LkEhm5xnMCuud7pt0Bu1ja7X8acK2qnfgRBXSsfBmQ4Vp20FkhlrEUtgdgkSoLKm5UtugE1an3Za23HZY2vyaFF3B6KHGe_WahUeFKOsllzUWeH9o0IM30ZMg-pdMth12mMYk-INAyEakRvPinf_oJswRp93NVE8f1jV8L_USucJnLchNzaTqDqrBS953gzN1Ol_qPxa7J0JHq3L8YOCD7sCE0NKEe3TkIyq6dDU_qFl_O3-Yp7gP5cFvwCXQcsr</recordid><startdate>20230506</startdate><enddate>20230506</enddate><creator>Burciaga-Hernandez, Luis A</creator><creator>Cueto-Villalobos, Cecilia F</creator><creator>Ortega-Piñon, Nancy</creator><creator>Gonzalez-Curiel, Irma E</creator><creator>Godina-Gonzalez, Susana</creator><creator>Mendez-Frausto, Gwendolyne</creator><creator>Aguilar-Esquivel, Anna P</creator><creator>Maldonado-Lagunas, Vilma</creator><creator>Guerrero-de la Torre, Luis E</creator><creator>Melendez-Zajgla, Jorge</creator><creator>Sanchez-Garcia, Erika K</creator><creator>Mitre-Aguilar, Irma B</creator><creator>Mendoza-Almanza, Gretel</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0340-9381</orcidid><orcidid>https://orcid.org/0000-0002-7254-5961</orcidid><orcidid>https://orcid.org/0000-0002-0044-9196</orcidid><orcidid>https://orcid.org/0000-0001-6955-9003</orcidid><orcidid>https://orcid.org/0000-0002-2209-1607</orcidid><orcidid>https://orcid.org/0000-0002-3277-2203</orcidid><orcidid>https://orcid.org/0000-0002-0426-7410</orcidid><orcidid>https://orcid.org/0000-0001-9668-1127</orcidid></search><sort><creationdate>20230506</creationdate><title>Gene Expression Behavior of a Set of Genes in Platelet and Tissue Samples from Patients with Breast Cancer</title><author>Burciaga-Hernandez, Luis A ; Cueto-Villalobos, Cecilia F ; Ortega-Piñon, Nancy ; Gonzalez-Curiel, Irma E ; Godina-Gonzalez, Susana ; Mendez-Frausto, Gwendolyne ; Aguilar-Esquivel, Anna P ; Maldonado-Lagunas, Vilma ; Guerrero-de la Torre, Luis E ; Melendez-Zajgla, Jorge ; Sanchez-Garcia, Erika K ; Mitre-Aguilar, Irma B ; Mendoza-Almanza, Gretel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-a01fa1ec3f69976852972096619dd3733e301d43641519923d35a1fae598d3713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Analysis</topic><topic>Angiogenesis</topic><topic>biomarkers panel</topic><topic>Biomolecules</topic><topic>Biopsy</topic><topic>Blood Platelets - 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,
,
,
,
,
,
, and
genes participates in breast cancer progression, angiogenesis, and metastasis. The present work aimed to analyze the expression levels of this set of genes in tumor tissues and platelets derived from breast cancer patients by reverse transcription-quantitative polymerase chain reaction (RTqPCR) assays, in order to determine if there was an expression correlation between these sources and to take advantage of the new information to be used in possible diagnosis by liquid biopsy. Data from these assays showed that platelets and breast cancer tumors present similar expression levels of a subset of these genes' mRNAs, depending on the molecular subtype, comorbidities, and metastasis presence.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37176055</pmid><doi>10.3390/ijms24098348</doi><orcidid>https://orcid.org/0000-0003-0340-9381</orcidid><orcidid>https://orcid.org/0000-0002-7254-5961</orcidid><orcidid>https://orcid.org/0000-0002-0044-9196</orcidid><orcidid>https://orcid.org/0000-0001-6955-9003</orcidid><orcidid>https://orcid.org/0000-0002-2209-1607</orcidid><orcidid>https://orcid.org/0000-0002-3277-2203</orcidid><orcidid>https://orcid.org/0000-0002-0426-7410</orcidid><orcidid>https://orcid.org/0000-0001-9668-1127</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2023-05, Vol.24 (9), p.8348 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
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| source | Access via ProQuest (Open Access); PubMed Central Free; Coronavirus Research Database |
| subjects | Age Analysis Angiogenesis biomarkers panel Biomolecules Biopsy Blood Platelets - metabolism Breast cancer Breast Neoplasms - metabolism Cancer Comorbidity Degranulation Deregulation Development and progression Disease Female Fibroblasts Gene Expression gene overexpression Genes Genetic aspects Genetic transcription Humans Membrane Proteins - metabolism Metastases Metastasis MicroRNA MicroRNAs MicroRNAs - genetics Oncogene Proteins - genetics Platelet-derived growth factor Polymerase chain reaction Reverse transcription RNA, Messenger - genetics RNA, Messenger - metabolism Tumor microenvironment Tumor Microenvironment - genetics tumor-educated platelets Tumors variation in mRNA levels Vascular endothelial growth factor Wiskott-Aldrich Syndrome Protein Family - metabolism |
| title | Gene Expression Behavior of a Set of Genes in Platelet and Tissue Samples from Patients with Breast Cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T22%3A53%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gene%20Expression%20Behavior%20of%20a%20Set%20of%20Genes%20in%20Platelet%20and%20Tissue%20Samples%20from%20Patients%20with%20Breast%20Cancer&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Burciaga-Hernandez,%20Luis%20A&rft.date=2023-05-06&rft.volume=24&rft.issue=9&rft.spage=8348&rft.pages=8348-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms24098348&rft_dat=%3Cgale_doaj_%3EA752423640%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c503t-a01fa1ec3f69976852972096619dd3733e301d43641519923d35a1fae598d3713%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2812605682&rft_id=info:pmid/37176055&rft_galeid=A752423640&rfr_iscdi=true |