Population-based study of the association between asthma and exogenous female sex hormone use

ObjectivesSeveral studies have suggested the influence of exogenous hormones on asthma, but the results are still conflicting. Moreover, there has been little associated research on Asian population. This study aimed to assess the association between use of exogenous female sex hormones and asthma i...

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Bibliographic Details
Published in:BMJ open 2021-12, Vol.11 (12), p.e046400-e046400
Main Authors: Jung, Won Jai, Lee, Sang Yeub, Choi, Sue In, Kim, Byung-Keun, Lee, Eun Joo, Choi, Jimi
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Asthma
Asthma - epidemiology
Body mass index
Epidemiology
Female
Gonadal Steroid Hormones
Hormone Replacement Therapy
Humans
Menopause
Menstruation
Middle Aged
Nutrition
Nutrition Surveys
Population
Population-based studies
Quality of life
Questionnaires
Republic of Korea - epidemiology
Respiratory Medicine
Risk Factors
sex steroids & HRT
Smoking
Statistical analysis
Tuberculosis
Urban areas
Womens health
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Summary:ObjectivesSeveral studies have suggested the influence of exogenous hormones on asthma, but the results are still conflicting. Moreover, there has been little associated research on Asian population. This study aimed to assess the association between use of exogenous female sex hormones and asthma in Korean women.DesignKorea National Health and Nutrition Examination Survey (KNHANES) is a nationwide programme to assess national health and nutritional status in Korea. A population-based study was conducted to analyse the relationship between self-reported asthma and exogenous hormones using the KNHANES between 2007 and 2012.ParticipantsThe study sample included 6874 premenopausal and 4912 postmenopausal women aged 30–65.Outcome measuresKNHANES data comprised health interviews and physical examinations. Questionnaires regarding asthma, reproductive factors and exogenous hormones were included.ResultsAmong postmenopausal women, 3.4% reported doctor-diagnosed asthma. Hormone replacement therapy (HRT) was associated with increased odds of doctor-diagnosed asthma (OR 1.56; 95% CI 1.04 to 2.35), while the association between HRT and wheeze in the last 1 year was not significant (OR 1.37; 95% CI 0.95 to 1.96). In premenopausal women, the prevalence of asthma was 2.3%. Use of oral contraceptives (OCs) was associated with an increased odds of doctor-diagnosed asthma (OR 1.67; 95% CI 1.01 to 2.76) and wheeze in the last 1 year (OR 1.88; 95% CI 1.31 to 2.69). These associations were dominant among non-obese women (body mass index
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2020-046400