Liposomal doxorubicin-related palmar–plantar erythrodysesthesia (hand–foot syndrome): a case report

Hand–foot syndrome (HFS) is a skin toxicity that occurs in areas of compressed skin. HFS manifests mainly in insensitive palms and the soles of the feet or in erythematous areas on the extremities caused by chemotherapy, which may be related to the dosage. This paper reports a case of HFS caused by...

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Bibliographic Details
Published in:Journal of international medical research 2020-12, Vol.48 (12), p.300060520974854-300060520974854
Main Authors: Ni, Chenxu, Fang, Juemin, Qian, Hong, Xu, Qing, Shen, Fuming
Format: Article
Language:English
Subjects:
Case Report
Case reports
Doxorubicin - adverse effects
Doxorubicin - analogs & derivatives
Drug therapy
Erythema
Erythema - chemically induced
Female
Foot diseases
Hand-Foot Syndrome - diagnosis
Hand-Foot Syndrome - etiology
Humans
Middle Aged
Polyethylene Glycols
Side effects
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Summary:Hand–foot syndrome (HFS) is a skin toxicity that occurs in areas of compressed skin. HFS manifests mainly in insensitive palms and the soles of the feet or in erythematous areas on the extremities caused by chemotherapy, which may be related to the dosage. This paper reports a case of HFS caused by liposomal doxorubicin. A 64-year-old Asian woman presented with severe erythema, ulceration, pruritus, and edema-related pain in her back, hands, and feet after receiving four cycles of liposomal doxorubicin. Clinicians and a pharmacist analyzed and evaluated the patient’s adverse reactions. After symptomatic treatment and patient education, her HFS symptoms were significantly relieved. The purpose of this study was to raise clinical awareness regarding adverse events following liposomal doxorubicin injection, and to provide new ideas for the clinical treatment of these adverse events.
ISSN:0300-0605
1473-2300
DOI:10.1177/0300060520974854