Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology

Background Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. Nanomedicine, a term for the application of nanotechnology in medical and health fields, uses nanoparticles for several applications such as imaging, diagnostic, targeted cancer therap...

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Published in:EJNMMI radiopharmacy and chemistry 2022-04, Vol.7 (1), p.8-36, Article 8
Main Authors: Pijeira, Martha Sahylí Ortega, Viltres, Herlys, Kozempel, Jan, Sakmár, Michal, Vlk, Martin, İlem-Özdemir, Derya, Ekinci, Meliha, Srinivasan, Seshasai, Rajabzadeh, Amin Reza, Ricci-Junior, Eduardo, Alencar, Luciana Magalhães Rebelo, Al Qahtani, Mohammed, Santos-Oliveira, Ralph
Format: Article
Language:English
Subjects:
Biomedical materials
Cancer
Copper-64
Gene transfer
Imaging
Lutetium
Lutetium-177
Medical imaging
Medicine
Medicine & Public Health
Molecular imaging
Molecular Medicine
Nanomaterials
Nanoparticles
Nanotechnology
Nuclear Chemistry
Nuclear Medicine
Pharmacotherapy
Precision medicine
Radiation therapy
Radioisotopes
Radiolabeled nanoparticles
Radiology
Radium
Radium-223
Review
State-of-the-art reviews
Technetium
Technetium isotopes
Technetium-99m
Tissue engineering
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Summary:Background Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. Nanomedicine, a term for the application of nanotechnology in medical and health fields, uses nanoparticles for several applications such as imaging, diagnostic, targeted cancer therapy, drug and gene delivery, tissue engineering, and theranostics. Results Here, we overview the current state-of-the-art of radiolabeled nanoparticles for molecular imaging and radionuclide therapy. Nanostructured radiopharmaceuticals of technetium-99m, copper-64, lutetium-177, and radium-223 are discussed within the scope of this review article. Conclusion Nanoradiopharmaceuticals may lead to better development of theranostics inspired by ingenious delivery and imaging systems. Cancer nano-theranostics have the potential to lead the way to more specific and individualized cancer treatment. Graphical abstract
ISSN:2365-421X
2365-421X
DOI:10.1186/s41181-022-00161-4