Applications of Adductomics in Chemically Induced Adverse Outcomes and Major Emphasis on DNA Adductomics: A Pathbreaking Tool in Biomedical Research

• Published in: International journal of molecular sciences 2021-09, Vol.22 (18), p.10141
• Main Authors: Behl, Tapan, Rachamalla, Mahesh, Najda, Agnieszka, Sehgal, Aayush, Singh, Sukhbir, Sharma, Neelam, Bhatia, Saurabh, Al-Harrasi, Ahmed, Chigurupati, Sridevi, Vargas-De-La-Cruz, Celia, Hobani, Yahya Hasan, Mohan, Syam, Goyal, Amit, Katyal, Taruna, Solarska, Ewa, Bungau, Simona
• Format: Article
• Language: English
• Subjects: adductomics; Adducts; Air pollution; Biocompatibility; Biomarkers; Biomedical research; Cancer; cancer detection tool; Carcinogenesis; Carcinogens; Chemotherapy; Chronic illnesses; Contaminants; Cytochrome; Data processing; Diagnosis; Disease prevention; DNA adduct; DNA adducts; Environmental quality; Etiology; Food contamination; Genotoxicity; Hydrocarbons; Indoor air quality; Investigations; Low concentrations; Mass spectrometry; Medical research; Metabolites; Methods; Pathogenesis; Plasma; Pollutants; protein adduct; Proteins; Review; Risk assessment; Scientific imaging; Tobacco smoking
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms221810141

Adductomics novel and emerging discipline in the toxicological research emphasizes on adducts formed by reactive chemical agents with biological molecules in living organisms. Development in analytical methods propelled the application and utility of adductomics in interdisciplinary sciences. This review endeavors to add a new dimension where comprehensive insights into diverse applications of adductomics in addressing some of society’s pressing challenges are provided. Also focuses on diverse applications of adductomics include: forecasting risk of chronic diseases triggered by reactive agents and predicting carcinogenesis induced by tobacco smoking; assessing chemical agents’ toxicity and supplementing genotoxicity studies; designing personalized medication and precision treatment in cancer chemotherapy; appraising environmental quality or extent of pollution using biological systems; crafting tools and techniques for diagnosis of diseases and detecting food contaminants; furnishing exposure profile of the individual to electrophiles; and assisting regulatory agencies in risk assessment of reactive chemical agents. Characterizing adducts that are present in extremely low concentrations is an exigent task and more over absence of dedicated database to identify adducts is further exacerbating the problem of adduct diagnosis. In addition, there is scope of improvement in sample preparation methods and data processing software and algorithms for accurate assessment of adducts.