Genetically Related Avian Influenza H7N9 Viruses Exhibit Different Pathogenicity in Mice

Avian influenza viruses can cross species barriers and adapt to mammals. The H7N9 subtype AIV that emerged in China in 2013 caused 1568 human infections, with a mortality rate of nearly 40%. We conducted a retrospective analysis of H7N9 viruses that were isolated in live poultry markets in 2013. We...

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Bibliographic Details
Published in:Animals (Basel) 2023-11, Vol.13 (23), p.3680
Main Authors: Wang, Xiaoquan, Zheng, Huafen, Gao, Ruyi, Ren, Leyao, Jin, Mingxia, Ji, Zhuxing, Wang, Xin, Lu, Xiaolong, Yang, Wenhao, Gu, Min, Liu, Xiaowen, Hu, Shunlin, Liu, Kaituo, Liu, Xiufan
Format: Article
Language:English
Subjects:
Adaptation
Avian flu
Avian influenza
Avian influenza viruses
Committees
Eggs
Embryos
Genes
Genomics
H7N9
Infection
Infections
Laboratory animals
Lungs
Maximum likelihood method
mice
pathogenicity
Pathogens
PB2-E627K
Phylogenetics
Poultry
Proteins
Viruses
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Summary:Avian influenza viruses can cross species barriers and adapt to mammals. The H7N9 subtype AIV that emerged in China in 2013 caused 1568 human infections, with a mortality rate of nearly 40%. We conducted a retrospective analysis of H7N9 viruses that were isolated in live poultry markets in 2013. We found that two avian-origin H7N9 isolates, A/chicken/Eastern China/JTC4/2013 and A/chicken/Eastern China/JTC11/2013, have a similar genetic background but exhibit different pathogenicity in mice. Whole-genome alignment of the two H7N9 viruses was carried out, and only six amino acid differences mapped in five genes, including the well-known virulence molecular marker PB2-E627K. Our retrospective analysis highlighted the importance of monitoring the adaptive mutations in avian influenza viruses with zoonotic potential.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani13233680