Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization

While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2023-01, Vol.56, p.e02652023-e02652023
Main Authors: Zaniolo, Larissa Marchi, Damazo, Amílcar Sabino
Format: Article
Language:English
Subjects:
Immune response
Interleukin-17
Leprosy
Leprosy reaction
Review
TROPICAL MEDICINE
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Summary:While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1β and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0265-2023