Amount of physical activity necessary for a normal level of high-sensitivity C-reactive protein in ELSA-Brasil: a cross-sectional study

Studies have shown that physical activity levels can be inversely associated with high-sensitivity C-reactive protein (hs-CRP) levels. However, the amount of physical activity required to maintain normal hs-CRP levels is still a matter for speculation. To identify the amount of physical activity nec...

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Published in:São Paulo medical journal 2020-01, Vol.138 (1), p.19-26
Main Authors: Queiroz, Ciro Oliveira, Pitanga, Francisco, Lotufo, Paulo Andrade, Molina, Maria Del Carmen Bisi, Aquino, Estela Maria Leão de, Almeida, Maria Conceição Chagas
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Chronic diseases
ELSA-Brasil
Exercises
Inflammation
MEDICINE, GENERAL & INTERNAL
Motor activity
Original
Risk factors
ROC curve
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Summary:Studies have shown that physical activity levels can be inversely associated with high-sensitivity C-reactive protein (hs-CRP) levels. However, the amount of physical activity required to maintain normal hs-CRP levels is still a matter for speculation. To identify the amount of physical activity necessary to discriminate the hs-CRP levels in adults. Cross-sectional study at six teaching and research institutions. The study sample comprised 10,231 adults aged 35 to 74 years who were participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Receiver operating characteristic (ROC) curves were constructed to compare the amount of physical activity in two domains (leisure time and commuting) with hs-CRP levels. The sensitivity and specificity were calculated to identify the best cutoff for physical activity level that would be needed to maintain normal levels of hs-CRP (< 3 mg/l). The area under the ROC curve was only statistically significant for discriminating normal levels of hs-CRP according to the amount of physical activity when the two study domains were added together. The accumulated physical activity level of 200 minutes/week was the best cutoff for discriminating normal levels of hs-CRP in adults of both sex. Physical activity in the leisure-time and commuting domains together, of duration 200 minutes/week, was associated with normal hs-CRP values.
ISSN:1516-3180
1806-9460
1806-9460
DOI:10.1590/1516-3180.2019.0301.r2.20102019