Modeling of the high-resolution optical-coherence diagnostics of bi-refringent biological tissues

We present a computer model of the polarization-sensitive interference diagnostics of the bi-refringent biological media, with a particular example of the lamella of eye cornea. The diagnostic procedure employs the modified Mach–Zehnder interferometer with controllable phase retardation of the refer...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in physics 2023-09, Vol.11
Main Authors: Angelsky, O. V., Bekshaev, A. Ya, Zenkova, C. Yu, Ivanskyi, D. I., Zheng, J., Chumak, M. M.
Format: Article
Language:English
Subjects:
bi-refringence
biological tissue
light polarization
object wave
partial coherence
reference wave
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present a computer model of the polarization-sensitive interference diagnostics of the bi-refringent biological media, with a particular example of the lamella of eye cornea. The diagnostic procedure employs the modified Mach–Zehnder interferometer with controllable phase retardation of the reference wave, separate observation of the orthogonal linearly-polarized interference signals, and evaluation of the phases and amplitudes of their variable (AC) components. The data obtained permit to determine the mean refractive index as well as the difference between the extraordinary and ordinary refractive indices, which, in turn, indicates the optical axis and the collagen fibers’ orientation in the lamella. The modelled procedure enables the sample structure diagnostics with the longitudinal and lateral resolution ∼100 nm and ∼1.8 μm, correspondingly. In particular, it permits a reliable detection and quantitative characterization of a thin (
ISSN:2296-424X
2296-424X
DOI:10.3389/fphy.2023.1260830