The relationship between frailty, nutritional status, co-morbidity, CT-body composition and systemic inflammation in patients with COVID-19

Frailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes including mortality in patients with COVID-19. However, the relationship between frailty and other recognised prognostic factors including age, nutritional status...

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Bibliographic Details
Published in:Journal of translational medicine 2022-02, Vol.20 (1), p.98-98, Article 98
Main Authors: McGovern, Josh, Al-Azzawi, Yassir, Kemp, Olivia, Moffitt, Peter, Richards, Conor, Dolan, Ross D, Laird, Barry J, McMillan, Donald C, Maguire, Donogh
Format: Article
Language:English
Subjects:
Aged
Body Composition
Canada
Comorbidity
Complications and side effects
COVID-19
COVID-19 - diagnostic imaging
COVID-19 - epidemiology
Elderly
Female
Frail elderly
Frailty
Frailty - diagnostic imaging
Frailty - epidemiology
Health aspects
Humans
Inflammation - diagnostic imaging
Inflammation - epidemiology
Male
Malnutrition
Nutritional Status
SARS-CoV-2
Tomography, X-Ray Computed
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Summary:Frailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes including mortality in patients with COVID-19. However, the relationship between frailty and other recognised prognostic factors including age, nutritional status, obesity, sarcopenia and systemic inflammation is poorly understood. Therefore, the aim of this study was to examine the relationship between frailty and other prognostic domains, in patients admitted with COVID-19. Patients who presented to our institutions between 1st April 2020-6th July 2020 with confirmed COVID-19 were assessed for inclusion. Data collected included general demographic details, clinicopathological variables, CFS admission assessment, Malnutrition Universal Screening Tool (MUST), CT-BC measurements and markers of systemic inflammation. 106 patients met the study inclusion criteria. The majority of patients were aged ≥ 70 years (67%), male (53%) and frail (scoring > 3 on the CFS, 72%). The majority of patients were not malnourished (MUST 0, 58%), had ≥ 1 co-morbidity (87%), were sarcopenic (low SMI, 80%) and had systemic inflammation (mGPS ≥ 1, 81%, NLR > 5, 55%). On multivariate binary logistics regression analysis, age (p 
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-022-03300-2