The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy

Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression throu...

Full description

Saved in:
Bibliographic Details
Published in:Cell & bioscience 2024-03, Vol.14 (1), p.39-19, Article 39
Main Authors: Gandhi, Pranali, Wang, Yuzhi, Li, Guigang, Wang, Shusheng
Format: Article
Language:English
Subjects:
Age
Analysis
Angiogenesis
Animal models
Antisense RNA
Blood vessels
Cornea
Diabetes
Diabetes mellitus
Diabetics
Edema
Eye disease
Eye diseases
Gene expression
Genes
Hypoxia
Intestinal obstruction
Lasers
Localization
Long noncoding RNA (lncRNA)
Macular degeneration
Medical research
Medicine, Experimental
Neovascularization
Non-coding RNA
Nonsteroidal anti-inflammatory drugs
Nucleotides
Ocular
Permeability
Physiological aspects
Physiology
Proteins
Retina
Retinopathy
Review
Sickle cell disease
Steroids
Transplants & implants
Vascular endothelial growth factor
Vascularization
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible for various vascular oculopathies, including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, and corneal neovascularization. While anti-VEGF treatment is available, it is not curative, and long-term outcomes are suboptimal, and some patients are unresponsive. To better understand these diseases, researchers have investigated the role of lncRNAs in regulating angiogenesis and models of vascular oculopathies. This review summarizes recent research on lncRNAs in ocular angiogenesis, including the pro-angiogenic lncRNAs ANRIL, HOTAIR, HOTTIP, H19, IPW, MALAT1, MIAT, NEAT1, and TUG1, the anti-angiogenic lncRNAs MEG3 and PKNY, and the human/primate specific lncRNAs lncEGFL7OS, discussing their functions and mechanisms of action in vascular oculopathies.
ISSN:2045-3701
2045-3701
DOI:10.1186/s13578-024-01217-5