Pilot study of circulating cell-free mitochondrial DNA in relation to brain structure in youth bipolar disorder

Background Mitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Higher circulating cell-free mitochondrial DNA (ccf-mtDNA), generally reflecting poorer mitochondrial health, has been associated with greater symptoms severity in BD. The current study examines the as...

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Bibliographic Details
Published in:International Journal of Bipolar Disorders 2024-06, Vol.12 (1), p.21-21
Main Authors: Shao, Suyi, Zou, Yi, Kennedy, Kody G., Dimick, Mikaela K., Andreazza, Ana C., Young, L. Trevor, Goncalves, Vanessa F., MacIntosh, Bradley J., Goldstein, Benjamin I.
Format: Article
Language:English
Subjects:
Behavioral Therapy
Bipolar disorder
Clinical Psychology
Magnetic resonance imaging
Medicine
Medicine & Public Health
Mitochondria
Mitochondrial DNA
mtDNA
Neurology
Psychiatry
Psychopharmacology
Psychotherapy
Youth
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Summary:Background Mitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Higher circulating cell-free mitochondrial DNA (ccf-mtDNA), generally reflecting poorer mitochondrial health, has been associated with greater symptoms severity in BD. The current study examines the association of serum ccf-mtDNA and brain structure in relation to youth BD. We hypothesized that higher ccf-mtDNA will be associated with measures of lower brain structure, particularly in the BD group. Methods Participants included 40 youth (BD, n  = 19; Control group [CG], n  = 21; aged 13–20 years). Serum ccf-mtDNA levels were assayed. T1-weighted brain images were acquired using 3T-MRI. Region of interest (ROI) analyses examined prefrontal cortex (PFC) and whole brain gray matter, alongside exploratory vertex-wise analyses. Analyses examined ccf-mtDNA main-effects and ccf-mtDNA-by-diagnosis interaction effects controlling for age, sex, and intracranial volume. Results There was no significant difference in ccf-mtDNA levels between BD and CG. In ROI analyses, higher ccf-mtDNA was associated with higher PFC surface area (SA) (β = 0.32 p  
ISSN:2194-7511
2194-7511
DOI:10.1186/s40345-024-00334-x