An Overview of Cannabidiol as a Multifunctional Drug: Pharmacokinetics and Cellular Effects

Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis Sativa, has garnered increasing attention for its diverse therapeutic potential. This comprehensive review delves into the complex pharmacokinetics of CBD, including factors such as bioavailability, distribution, safety profile, an...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-01, Vol.29 (2), p.473
Main Authors: Martinez Naya, Nadia, Kelly, Jazmin, Corna, Giuliana, Golino, Michele, Polizio, Ariel H, Abbate, Antonio, Toldo, Stefano, Mezzaroma, Eleonora
Format: Article
Language:English
Subjects:
anti-inflammatory
antioxidant
B cells
Bioavailability
Biological Availability
Biological response modifiers
Cannabidiol
Cannabidiol - pharmacology
Cannabidiol - therapeutic use
Cannabinoid Receptor Agonists
Cannabis
Carbidopa
CBD
cellular effects
Drug dosages
Free radicals
Hallucinogens
Health aspects
Hemp
Humans
Interferon
Marijuana
Metabolism
Oral administration
Pharmacokinetics
Plasma
Review
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Summary:Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis Sativa, has garnered increasing attention for its diverse therapeutic potential. This comprehensive review delves into the complex pharmacokinetics of CBD, including factors such as bioavailability, distribution, safety profile, and dosage recommendations, which contribute to the compound's pharmacological profile. CBD's role as a pharmacological inhibitor is explored, encompassing interactions with the endocannabinoid system and ion channels. The compound's anti-inflammatory effects, influencing the Interferon-beta and NF-κB, position it as a versatile candidate for immune system regulation and interventions in inflammatory processes. The historical context of Cannabis Sativa's use for recreational and medicinal purposes adds depth to the discussion, emphasizing CBD's emergence as a pivotal phytocannabinoid. As research continues, CBD's integration into clinical practice holds promise for revolutionizing treatment approaches and enhancing patient outcomes. The evolution in CBD research encourages ongoing exploration, offering the prospect of unlocking new therapeutic utility.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29020473