The Next Frontier in Lung Transplantation: Protecting the Endothelium and Repairing Organs for Transplant Utilizing MG53

Additionally, DAMPs can initiate release of tumor necrosis factor-alpha (TNF-α), which when bound to its receptors recruits cytosolic adaptor proteins to form complex I (which contains RIPK1) and complex II. [...]local elevation of calcium ions allows of fusion of the aforementioned vesicles with th...

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Bibliographic Details
Published in:Clinical and translational discovery 2023-12, Vol.3 (6), p.n/a
Main Authors: Gouchoe, Doug A., Whitson, Bryan A., Zhu, Hua
Format: Article
Language:English
Subjects:
Conflicts of interest
Cytokines
Edema
Endothelium
Immune system
Inflammation
Ischemia
Kinases
Lung transplants
Neutrophils
Postoperative period
Proteins
Tumor necrosis factor-TNF
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Summary:Additionally, DAMPs can initiate release of tumor necrosis factor-alpha (TNF-α), which when bound to its receptors recruits cytosolic adaptor proteins to form complex I (which contains RIPK1) and complex II. [...]local elevation of calcium ions allows of fusion of the aforementioned vesicles with the plasma membrane to form the repair patch (i.e., a “plug and patch” technique). First described by Jia et al., rhMG53 administration during rodent models of acute lung injury (ALI) resulted in preserved tissue architecture and pulmonic function. While this study demonstrated the MG53 is protective against over-ventilation induced ALI, and is generated by alveolar epithelial cells as well, it was unclear if rhMG53 administration resulted in all membranes being repaired, or if individual cell populations were being targeted.
ISSN:2768-0622
2768-0622
DOI:10.1002/ctd2.255