Nutrient-Mediated Perception and Signalling in Human Metabolism: A Perspective of Nutrigenomics

The interaction between selective nutrients and linked genes involving a specific organ reveals the genetic make-up of an individual in response to a particular nutrient. The interaction of genes with food opens opportunities for the addition of bioactive compounds for specific populations comprisin...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (19), p.11305
Main Authors: Lal, Milan Kumar, Sharma, Eshita, Tiwari, Rahul Kumar, Devi, Rajni, Mishra, Udit Nandan, Thakur, Richa, Gupta, Rucku, Dey, Abhijit, Lal, Priyanka, Kumar, Awadhesh, Altaf, Muhammad Ahsan, Sahu, Durgesh Nandini, Kumar, Ravinder, Singh, Brajesh, Sahu, Sunil Kumar
Format: Article
Language:English
Subjects:
Bioactive compounds
Dietary supplements
epigenetics
Genes
Genomics
Genotypes
hormones
human diet
Kinases
Lipid metabolism
Lipids
Metabolites
mTOR
nutrient sensing pathways
Nutrients
nutrigenomics
Nutrition research
Review
Signal transduction
Sugar
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The interaction between selective nutrients and linked genes involving a specific organ reveals the genetic make-up of an individual in response to a particular nutrient. The interaction of genes with food opens opportunities for the addition of bioactive compounds for specific populations comprising identical genotypes. The slight difference in the genetic blueprints of humans is advantageous in determining the effect of nutrients and their metabolism in the body. The basic knowledge of emerging nutrigenomics and nutrigenetics can be applied to optimize health, prevention, and treatment of diseases. In addition, nutrient-mediated pathways detecting the cellular concentration of nutrients such as sugars, amino acids, lipids, and metabolites are integrated and coordinated at the organismal level via hormone signals. This review deals with the interaction of nutrients with various aspects of nutrigenetics and nutrigenomics along with pathways involved in nutrient sensing and regulation, which can provide a detailed understanding of this new leading edge in nutrition research and its potential application to dietetic practice.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231911305