Enhancer-derived long non-coding RNAs CCAT1 and CCAT2 at rs6983267 has limited predictability for early stage colorectal carcinoma metastasis

Up-regulation of long non-coding RNAs (lncRNAs), colon-cancer associated transcript ( CCAT ) 1 and 2 , was associated with worse prognosis in colorectal cancer (CRC). Nevertheless, their role in predicting metastasis in early-stage CRC is unclear. We measured the expression of CCAT1 , CCAT2 and thei...

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Published in:Scientific reports 2021-01, Vol.11 (1), p.404-404, Article 404
Main Authors: Thean, Lai Fun, Blöcker, Christopher, Li, Hui Hua, Lo, Michelle, Wong, Michelle, Tang, Choong Leong, Tan, Emile K. W., Rozen, Steven G., Cheah, Peh Yean
Format: Article
Language:English
Subjects:
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c-Myc protein
Colon cancer
Colorectal cancer
Colorectal carcinoma
Genotypes
Humanities and Social Sciences
Metastases
Metastasis
Mucosa
multidisciplinary
Myc protein
Non-coding RNA
Polymerase chain reaction
Science
Science (multidisciplinary)
Transcription
Tumors
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Summary:Up-regulation of long non-coding RNAs (lncRNAs), colon-cancer associated transcript ( CCAT ) 1 and 2 , was associated with worse prognosis in colorectal cancer (CRC). Nevertheless, their role in predicting metastasis in early-stage CRC is unclear. We measured the expression of CCAT1 , CCAT2 and their oncotarget, c-Myc , in 150 matched mucosa-tumour samples of early-stage microsatellite-stable Chinese CRC patients with definitive metastasis status by multiplex real-time RT-PCR assay. Expression of CCAT1 , CCAT2 and c-Myc were significantly up-regulated in the tumours compared to matched mucosa ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-79906-7